Steroid receptors and action in the primate follicle

Mary B. Zelinski-Wooten, Richard L. Stouffer

    Research output: Contribution to journalShort survey

    14 Scopus citations

    Abstract

    Studies localizing steroid receptor (R) proteins and their mRNAs to the primate ovary are consistent with a local role for progesterone (P) and androgen (A) in modulating follicle growth and/or maturation via classic R- mediated pathways, but data in support of estrogen (E) action remain equivocal. Investigations of the hypothesis that steroids play a pivotal role in folliculogenesis or gametogenesis in macaques receiving inhibitors of steroid enzyme synthesis and in women with congenital steroid enzyme deficiencies reveal that (a) antral follicle growth, maturation, and luteinization, as well as oocyte meiosis, do not require high or increasing E levels; (b) elevated A to E ratios are detrimental to the gametogenic functions of the primate follicle, but do not alter growth and maturation of antral follicles; and (c) ovulation and luteinization of the mature follicle are dependent on local P actions. The genomic actions of steroids likely vary between compartments and with the developmental state of the follicle; however, potential nongenomic actions of steroids in follicles remain largely undefined. Future advances will rely on identification of discrete biochemical, morphological and functional correlates of steroid hormone action in the somatic and gametogenic compartments of the primate follicle throughout its life cycle.

    Original languageEnglish (US)
    Pages (from-to)177-183
    Number of pages7
    JournalTrends in Endocrinology and Metabolism
    Volume7
    Issue number5
    DOIs
    StatePublished - Jul 1996

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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