Steroid receptors and action in the primate follicle

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Studies localizing steroid receptor (R) proteins and their mRNAs to the primate ovary are consistent with a local role for progesterone (P) and androgen (A) in modulating follicle growth and/or maturation via classic R- mediated pathways, but data in support of estrogen (E) action remain equivocal. Investigations of the hypothesis that steroids play a pivotal role in folliculogenesis or gametogenesis in macaques receiving inhibitors of steroid enzyme synthesis and in women with congenital steroid enzyme deficiencies reveal that (a) antral follicle growth, maturation, and luteinization, as well as oocyte meiosis, do not require high or increasing E levels; (b) elevated A to E ratios are detrimental to the gametogenic functions of the primate follicle, but do not alter growth and maturation of antral follicles; and (c) ovulation and luteinization of the mature follicle are dependent on local P actions. The genomic actions of steroids likely vary between compartments and with the developmental state of the follicle; however, potential nongenomic actions of steroids in follicles remain largely undefined. Future advances will rely on identification of discrete biochemical, morphological and functional correlates of steroid hormone action in the somatic and gametogenic compartments of the primate follicle throughout its life cycle.

    Original languageEnglish (US)
    Pages (from-to)177-183
    Number of pages7
    JournalTrends in Endocrinology and Metabolism
    Volume7
    Issue number5
    DOIs
    StatePublished - Jul 1996

    Fingerprint

    Steroid Receptors
    Primates
    Steroids
    Luteinization
    Growth
    Gametogenesis
    Meiosis
    Macaca
    Ovulation
    Life Cycle Stages
    Androgens
    Action Potentials
    Oocytes
    Progesterone
    Ovary
    Estrogens
    Hormones
    Messenger RNA
    Enzymes
    Proteins

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Steroid receptors and action in the primate follicle. / Zelinski, Mary; Stouffer, Richard.

    In: Trends in Endocrinology and Metabolism, Vol. 7, No. 5, 07.1996, p. 177-183.

    Research output: Contribution to journalArticle

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