Steroid biosynthesis in human adrenal tumors

R. D'Agata, S. Malozowski, A. Barkan, F. Cassorla, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

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Abstract

Patients with adrenal tumors presented with varied clinical features which may be related to differing patterns of adrenal steroidogenesis. To explore the mechanism underlying these differences, we studied the in vitro activities of 3β-hydroxysteroid dehydrogenase (3β-HSD), 17-hydroxylase (17-OH), 21-hydroxylase (21-OH), and 17-20 desmolase (17,20-D) in 6 adrenal tumors, 4 adenomas and 2 carcinomas. Normal human adrenal tissue was also studied for comparison. Adrenal adenomas had increased 21-OH activity compared with normal adrenal tissue (11.4 ± 0.7 vs 5.5 ± 0.5 nmol/mg prot/min, P <0.002) and with adrenal carcinomas (11.4 ± 0.7 vs 3.3 ± 0.9 nmol/mg prot/min, P <0.001). Carcinomas had reduced 3β-HSD, 17-OH and 17,20-D activities when compared to controls, but this did not reach statistical significance. These observations suggest less efficient steroidogenesis by adrenal carcinomas, a finding which may explain the large size of these tumors when the symptoms of hypercortisolism first appear.

Original languageEnglish (US)
Pages (from-to)386-388
Number of pages3
JournalHormone and Metabolic Research
Volume19
Issue number8
StatePublished - 1987
Externally publishedYes

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Glandular and Epithelial Neoplasms
Biosynthesis
3-Hydroxysteroid Dehydrogenases
Tumors
Steroids
Carcinoma
Adenoma
Tissue
Steroid 17-alpha-Hydroxylase
Steroid 21-Hydroxylase
Mixed Function Oxygenases
Cushing Syndrome
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

D'Agata, R., Malozowski, S., Barkan, A., Cassorla, F., & Loriaux, D. L. (1987). Steroid biosynthesis in human adrenal tumors. Hormone and Metabolic Research, 19(8), 386-388.

Steroid biosynthesis in human adrenal tumors. / D'Agata, R.; Malozowski, S.; Barkan, A.; Cassorla, F.; Loriaux, Donald (Lynn).

In: Hormone and Metabolic Research, Vol. 19, No. 8, 1987, p. 386-388.

Research output: Contribution to journalArticle

D'Agata, R, Malozowski, S, Barkan, A, Cassorla, F & Loriaux, DL 1987, 'Steroid biosynthesis in human adrenal tumors', Hormone and Metabolic Research, vol. 19, no. 8, pp. 386-388.
D'Agata R, Malozowski S, Barkan A, Cassorla F, Loriaux DL. Steroid biosynthesis in human adrenal tumors. Hormone and Metabolic Research. 1987;19(8):386-388.
D'Agata, R. ; Malozowski, S. ; Barkan, A. ; Cassorla, F. ; Loriaux, Donald (Lynn). / Steroid biosynthesis in human adrenal tumors. In: Hormone and Metabolic Research. 1987 ; Vol. 19, No. 8. pp. 386-388.
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