@inbook{6708b352434e434e82acf632c25876dc,
title = "Stereotaxic surgical targeting of the nonhuman primate caudate and putamen: Gene therapy for huntington{\textquoteright}s disease",
abstract = "Stereotaxic surgery is an invaluable tool to deliver a variety of gene therapy constructs to the nonhuman primate caudate and putamen in preclinical studies for the genetic, neurodegenerative disorder, Huntington{\textquoteright}s disease (HD). Here we describe in detail how to perform this technique beginning with a pre-surgical magnetic resonance imaging scan to determine surgical coordinates followed by the stereotaxic surgical injection technique. In addition, we include methodology of a full necropsy including brain and peripheral tissue removal and a standard immunohistochemical technique to visualize the injected gene therapy agent.",
keywords = "Huntington{\textquoteright}s disease, Immunohistochemistry, Magnetic resonance imaging, Necropsy, Neurodegeneration, Nonhuman primate, Stereotaxic surgery",
author = "McBride, {Jodi L.} and Clark, {Randall L.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",
year = "2016",
doi = "10.1007/978-1-4939-3271-9_29",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "409--428",
booktitle = "Methods in Molecular Biology",
}