Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts

Joshua P. Torres, Maria Diarey Tianero, Jose Miguel D. Robes, Jason C. Kwan, Jason S. Biggs, Gisela P. Concepcion, Baldomero M. Olivera, Margo Haygood, Eric W. Schmidta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cone snails are biomedically important sources of peptide drugs, but it is not known whether snail-associated bacteria affect venom chemistry. To begin to answer this question, we performed 16S rRNA gene amplicon sequencing of eight cone snail species, comparing their microbiomes with each other and with those from a variety of other marine invertebrates. We show that the cone snail microbiome is distinct from those in other marine invertebrates and conserved in specimens from around the world, including the Philippines, Guam, California, and Florida. We found that all venom ducts examined contain diverse 16S rRNA gene sequences bearing closest similarity to Stenotrophomonas bacteria. These sequences represent specific symbionts that live in the lumen of the venom duct, where bioactive venom peptides are synthesized.

Original languageEnglish (US)
Article numbere01418-17
JournalApplied and Environmental Microbiology
Volume83
Issue number23
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Mollusk Venoms
Stenotrophomonas
venom
Snails
Venoms
venoms
symbiont
symbionts
snail
snails
Bacteria
bacterium
Microbiota
bacteria
Invertebrates
rRNA Genes
peptide
invertebrate
Guam
invertebrates

Keywords

  • Cone snail
  • Natural products
  • Symbiosis
  • Venom duct

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

Cite this

Torres, J. P., Tianero, M. D., Robes, J. M. D., Kwan, J. C., Biggs, J. S., Concepcion, G. P., ... Schmidta, E. W. (2017). Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. Applied and Environmental Microbiology, 83(23), [e01418-17]. https://doi.org/10.1128/AEM.01418-17

Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. / Torres, Joshua P.; Tianero, Maria Diarey; Robes, Jose Miguel D.; Kwan, Jason C.; Biggs, Jason S.; Concepcion, Gisela P.; Olivera, Baldomero M.; Haygood, Margo; Schmidta, Eric W.

In: Applied and Environmental Microbiology, Vol. 83, No. 23, e01418-17, 01.01.2017.

Research output: Contribution to journalArticle

Torres, JP, Tianero, MD, Robes, JMD, Kwan, JC, Biggs, JS, Concepcion, GP, Olivera, BM, Haygood, M & Schmidta, EW 2017, 'Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts', Applied and Environmental Microbiology, vol. 83, no. 23, e01418-17. https://doi.org/10.1128/AEM.01418-17
Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP et al. Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. Applied and Environmental Microbiology. 2017 Jan 1;83(23). e01418-17. https://doi.org/10.1128/AEM.01418-17
Torres, Joshua P. ; Tianero, Maria Diarey ; Robes, Jose Miguel D. ; Kwan, Jason C. ; Biggs, Jason S. ; Concepcion, Gisela P. ; Olivera, Baldomero M. ; Haygood, Margo ; Schmidta, Eric W. / Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. In: Applied and Environmental Microbiology. 2017 ; Vol. 83, No. 23.
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