Stem cells versus plasticity in liver and pancreas regeneration

Janel L. Kopp, Markus Grompe, Maike Sander

Research output: Contribution to journalReview articlepeer-review

120 Scopus citations


Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalNature Cell Biology
Issue number3
StatePublished - Feb 25 2016

ASJC Scopus subject areas

  • Cell Biology


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