Stem cells versus plasticity in liver and pancreas regeneration

Janel L. Kopp, Markus Grompe, Maike Sander

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalNature Cell Biology
Volume18
Issue number3
DOIs
StatePublished - Feb 25 2016

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Liver Regeneration
Pancreas
Stem Cells
Cell Transdifferentiation
Liver
Cell Differentiation
Wounds and Injuries
Cell Plasticity

ASJC Scopus subject areas

  • Cell Biology

Cite this

Stem cells versus plasticity in liver and pancreas regeneration. / Kopp, Janel L.; Grompe, Markus; Sander, Maike.

In: Nature Cell Biology, Vol. 18, No. 3, 25.02.2016, p. 238-245.

Research output: Contribution to journalArticle

Kopp, Janel L. ; Grompe, Markus ; Sander, Maike. / Stem cells versus plasticity in liver and pancreas regeneration. In: Nature Cell Biology. 2016 ; Vol. 18, No. 3. pp. 238-245.
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