@article{aa227a204d8f4d1686f6c352b34a0976,
title = "Stem cells versus plasticity in liver and pancreas regeneration",
abstract = "Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.",
author = "Kopp, {Janel L.} and Markus Grompe and Maike Sander",
note = "Funding Information: We thank A. C. Carrano (Univ. California, USA) for help with writing the manuscript and constructive comments. We apologize to our colleagues whose references were omitted owing to space constraints. J.L.K. is supported by grants from the Juvenile Diabetes Research Foundation (JDRF), National Pancreatic Cancer Canada Foundation, Pancreas Centre British Columbia, Canadian Institutes of Health Research and the National Institutes of Health. M.G. is supported by grants from the National Institutes of Health (DK05192 and DK104143) and the Helmsley Charitable Trust. M.S. is supported by grants from the National Institutes of Health (DK078803 and DK068471), the JDRF, the Helmsley Charitable Trust and the California Institute for Regenerative Medicine. Funding Information: We thank A. C. Carrano (Univ. California, USA) for help with writing the manuscript and constructive comments. We apologize to our colleagues whose references were omitted owing to space constraints. J.L.K. is supported by grants from the Juvenile Diabetes Research Foundation (JDRF), National Pancreatic Cancer Canada Foundation, Pancreas Centre British Columbia, Canadian Institutes of Health Research and the National Institutes of Health. M.G. is supported by grants from the National Institutes of Health (DK05192 and DK104143) and the Helmsley Charitable Trust. M.S. is supported by grants from the National Institutes of Health (DK078803 and DK068471), the JDRF, the Helmsley Charitable Trust and the California Institute for Regenerative Medicine. Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited.",
year = "2016",
month = feb,
day = "25",
doi = "10.1038/ncb3309",
language = "English (US)",
volume = "18",
pages = "238--245",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "3",
}