Stellate Cells in Tissue Repair, Inflammation, and Cancer

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic state in the context of tissue injury. Beyond having roles in tissue homeostasis, stellate cells are increasingly implicated in pathological fibrogenic and lammatory programs that contribute to tissue fibrosis and that constitute a growth-permissive tumor microenvironment. Although the capacity of stellate cells for extracellular matrix production and remodeling has long been appreciated, recent research efforts have demonstrated diverse roles for stellate cells in regulation of epithelial cell fate, immune modulation, and tissue health. Our present understanding of stellate cell biology in health and disease is discussed here, as are emerging means to target these multifaceted cells for therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)333-355
Number of pages23
JournalAnnual Review of Cell and Developmental Biology
Volume34
DOIs
StatePublished - Oct 6 2018

Keywords

  • Fibrosis
  • Liver
  • Pancreas
  • Stellate cell
  • Tumor microenvironment
  • Wound healing

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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