Steatosis and cirrhosis in an obese diabetic - Resolution of fatty liver by fasting

Emmet B. Keeffe, Peter W. Adesman, Peter Stenzel, Robert M. Palmer

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

A 54-year-old woman with obesity, type II diabetes mellitus, hyperlipidemia, and massive hepatomegaly was found to have severe steatosis and cirrhosis on liver biopsy. Complete evaluation led to the diagnosis of fatty cirrhosis associated with obesity and diabetic mellitus. She underwent four months of fasting with a protein-carbohydrate and vitamin-mineral liquid supplement to control her weight and metabolic abnormalities and to evaluate the effect of this diet on her liver disease. She lost 40 pounds to ideal body weight, normalized her serum glucose and lipids, and decreased total liver height by one third. Liver biopsy at the completion of her diet showed inactive cirrhosis and complete resolution of steatosis. Supplemented fasting with only modest weight loss can safely resolve fatty liver in obese diabetics with nonalcoholic steatosis and cirrhosis. Aggressive dietary approaches to achieve long-term weight loss deserve study in this subgroup of diabetics with unexplained chronic liver disease.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalDigestive Diseases and Sciences
Volume32
Issue number4
DOIs
StatePublished - Apr 1987

Fingerprint

Fatty Liver
Fasting
Fibrosis
Liver Diseases
Weight Loss
Obesity
Diet
Biopsy
Ideal Body Weight
Hepatomegaly
Liver
Hyperlipidemias
Vitamins
Liver Cirrhosis
Type 2 Diabetes Mellitus
Minerals
Chronic Disease
Carbohydrates
Lipids
Weights and Measures

Keywords

  • fatty cirrhosis
  • fatty liver
  • nonalcoholic steatonecrosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Steatosis and cirrhosis in an obese diabetic - Resolution of fatty liver by fasting. / Keeffe, Emmet B.; Adesman, Peter W.; Stenzel, Peter; Palmer, Robert M.

In: Digestive Diseases and Sciences, Vol. 32, No. 4, 04.1987, p. 441-445.

Research output: Contribution to journalArticle

Keeffe, Emmet B. ; Adesman, Peter W. ; Stenzel, Peter ; Palmer, Robert M. / Steatosis and cirrhosis in an obese diabetic - Resolution of fatty liver by fasting. In: Digestive Diseases and Sciences. 1987 ; Vol. 32, No. 4. pp. 441-445.
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