TY - JOUR
T1 - Status of bcr-abl tyrosine kinase inhibitors in chronic myelogenous leukemia
AU - O'Dwyer, Michael E.
AU - Druker, Brian J.
PY - 2000
Y1 - 2000
N2 - The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, STI571 (formerly CGP57148B), an abl-specific, tyrosine kinase inhibitor, selectively killed bcr-abl-expressing cells both in vitro and in vivo. In early clinical trials of STI571, encouraging results have been obtained, and there is already a suggestion that STI571 may soon need to be incorporated into treatment algorithms for chronic myelogenous leukemia.
AB - The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, STI571 (formerly CGP57148B), an abl-specific, tyrosine kinase inhibitor, selectively killed bcr-abl-expressing cells both in vitro and in vivo. In early clinical trials of STI571, encouraging results have been obtained, and there is already a suggestion that STI571 may soon need to be incorporated into treatment algorithms for chronic myelogenous leukemia.
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U2 - 10.1097/00001622-200011000-00013
DO - 10.1097/00001622-200011000-00013
M3 - Review article
C2 - 11085460
AN - SCOPUS:0034509139
SN - 1040-8746
VL - 12
SP - 594
EP - 597
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
IS - 6
ER -