Statistical Methods of Analysis and Visualization of Extracellular Microelectrode Recordings

J. H. Falkenberg, J. McNames, Kim Burchiel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Determining neuronal structures during stereotactic surgery in Parkinson's disease (PD) patients is a prerequisite for optimal placement of deep brain stimulation electrodes and/or neuronal ablation. This study describes statistical signal processing methods that automatically analyze microelectrode recordings and display a neurophysiological brainmap of the stereotactic trajectory. The spontaneous signals along the trajectory were recorded during neurosurgery of PD patients and analyzed post surgery. Our approach applies characterizations and visualization of energy, marginal probability density function, power spectral density, the time-domain signal, the autocorrelation function and partial autocorrelation function of the microelectrode recordings at the different depths along the trajectory. These are novel analysis methods of microelectrode recordings and enable neurosurgeons to easily distinguish adjacent brain structures and characteristics within and between the neuronal structures even when spike detection is impossible.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages2515-2518
Number of pages4
Volume3
StatePublished - 2003
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Other

OtherA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period9/17/039/21/03

Fingerprint

Microelectrodes
Statistical methods
Visualization
Trajectories
Autocorrelation
Surgery
Brain
Neurosurgery
Power spectral density
Ablation
Probability density function
Signal processing
Electrodes

Keywords

  • Automatic microelectrode recording
  • Parkinson's disease
  • Statistical signal processing
  • Visualization

ASJC Scopus subject areas

  • Bioengineering

Cite this

Falkenberg, J. H., McNames, J., & Burchiel, K. (2003). Statistical Methods of Analysis and Visualization of Extracellular Microelectrode Recordings. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 3, pp. 2515-2518)

Statistical Methods of Analysis and Visualization of Extracellular Microelectrode Recordings. / Falkenberg, J. H.; McNames, J.; Burchiel, Kim.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. ed. / R.S. Leder. Vol. 3 2003. p. 2515-2518.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Falkenberg, JH, McNames, J & Burchiel, K 2003, Statistical Methods of Analysis and Visualization of Extracellular Microelectrode Recordings. in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 3, pp. 2515-2518, A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 9/17/03.
Falkenberg JH, McNames J, Burchiel K. Statistical Methods of Analysis and Visualization of Extracellular Microelectrode Recordings. In Leder RS, editor, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 3. 2003. p. 2515-2518
Falkenberg, J. H. ; McNames, J. ; Burchiel, Kim. / Statistical Methods of Analysis and Visualization of Extracellular Microelectrode Recordings. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. editor / R.S. Leder. Vol. 3 2003. pp. 2515-2518
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