Statin use and risk of prostate cancer in the prospective osteoporotic fractures in men (MrOS) study

June M. Chan, Stephanie Litwack-Harrison, Scott R. Bauer, Nicholas A. Daniels, Timothy J. Wilt, Jackilen (Jackie) Shannon, Douglas C. Bauer

Research output: Contribution to journalArticle

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Abstract

Background: Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways. The evidence of an association between statins and prostate cancer risk remains ambiguous. Methods: We examined statin use in a prospective cohort of 5,069 elderly U.S. men and the risk of incident total, low/high stage, and low/high grade prostate cancer diagnosed between 2000 and 2008. We used multivariate logistic regression models to estimate relative risks and 95% confidence intervals, adjusting for demographic and lifestyle characteristics. Results: There was no evidence of an association between statin use and any of the prostate cancer endpoints (total, low/high stage, low/high grade prostate cancer), adjusting for age, study site, race, body mass index, marital status, family history of prostate cancer, number of comorbidities, physical activity, and smoking history. Conclusions and Impact: In this study of elderly U.S. men, we observed a null association between statin use and risk of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1886-1888
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number10
DOIs
StatePublished - Oct 2012

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Osteoporotic Fractures
Prostatic Neoplasms
Logistic Models
Marital Status
Life Style
Comorbidity
Body Mass Index
Smoking
History
Cholesterol
Demography
Confidence Intervals
Exercise
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Chan, J. M., Litwack-Harrison, S., Bauer, S. R., Daniels, N. A., Wilt, T. J., Shannon, J. J., & Bauer, D. C. (2012). Statin use and risk of prostate cancer in the prospective osteoporotic fractures in men (MrOS) study. Cancer Epidemiology Biomarkers and Prevention, 21(10), 1886-1888. https://doi.org/10.1158/1055-9965.EPI-12-0816

Statin use and risk of prostate cancer in the prospective osteoporotic fractures in men (MrOS) study. / Chan, June M.; Litwack-Harrison, Stephanie; Bauer, Scott R.; Daniels, Nicholas A.; Wilt, Timothy J.; Shannon, Jackilen (Jackie); Bauer, Douglas C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 10, 10.2012, p. 1886-1888.

Research output: Contribution to journalArticle

Chan, JM, Litwack-Harrison, S, Bauer, SR, Daniels, NA, Wilt, TJ, Shannon, JJ & Bauer, DC 2012, 'Statin use and risk of prostate cancer in the prospective osteoporotic fractures in men (MrOS) study', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 10, pp. 1886-1888. https://doi.org/10.1158/1055-9965.EPI-12-0816
Chan, June M. ; Litwack-Harrison, Stephanie ; Bauer, Scott R. ; Daniels, Nicholas A. ; Wilt, Timothy J. ; Shannon, Jackilen (Jackie) ; Bauer, Douglas C. / Statin use and risk of prostate cancer in the prospective osteoporotic fractures in men (MrOS) study. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 10. pp. 1886-1888.
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AB - Background: Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways. The evidence of an association between statins and prostate cancer risk remains ambiguous. Methods: We examined statin use in a prospective cohort of 5,069 elderly U.S. men and the risk of incident total, low/high stage, and low/high grade prostate cancer diagnosed between 2000 and 2008. We used multivariate logistic regression models to estimate relative risks and 95% confidence intervals, adjusting for demographic and lifestyle characteristics. Results: There was no evidence of an association between statin use and any of the prostate cancer endpoints (total, low/high stage, low/high grade prostate cancer), adjusting for age, study site, race, body mass index, marital status, family history of prostate cancer, number of comorbidities, physical activity, and smoking history. Conclusions and Impact: In this study of elderly U.S. men, we observed a null association between statin use and risk of prostate cancer.

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