Statin therapy in patients with diastolic heart failure

Faramarz Tehrani, Ryan Morrissey, Anita Phan, Christopher Chien, Ernst R. Schwarz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: There is controversy regarding the potentialeffects of statintherapy onmortality in patientswith heart failure. The present study analyzed the possible effects of statin therapy on morbidity and mortality in patientswith diastolic heart failure over long-termfollow-up. Hypothesis: To evaluate potential effect of statin therapy on hospitalization rate andmortality in patientswith diastolic heart failure. Methods: Patientswith preserved left ventricular ejection fraction (≥50%), hospitalized for clinical symptoms of heart failure were evaluated. Patients on statin therapy started at or prior to their first heart failure admission representedgroup 1 and patientswithout statin therapy representedgroup 2. The effects of statins on hospitalization rates and mortality were assessed during a 5 year follow-up. Results: A total of 270 patients (group 1 n = 81; group 2 n = 189) were followed over 5 years. Patients on statinsdemonstratedimproved survival compared to patientswithout statintherapy (hazard ratio [HR]=0.65, 95% confidence interval [CI]: 0.45-0.95, P = .029). The survival benefit was maintained after adjusting for differences in baseline characteristics, comorbidities, and other medications. There was no significant difference in the mean cardiovascular hospitalization rate (3.0 ± 3.2 vs 3.8 ± 4.7, P = .23) and in overall hospitalization rate (7.1 ± 6.3 vs 7.8 ± 7.7, P = .52) between groups 1 and 2, respectively. Conclusion: Statin therapy appears to be associated with improved survival in patients with diastolic heart failure.

Original languageEnglish (US)
JournalClinical Cardiology
Volume33
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

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Diastolic Heart Failure
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hospitalization
Heart Failure
Survival
Therapeutics
Pyridinolcarbamate
Mortality
Stroke Volume
Comorbidity
Confidence Intervals
Morbidity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tehrani, F., Morrissey, R., Phan, A., Chien, C., & Schwarz, E. R. (2010). Statin therapy in patients with diastolic heart failure. Clinical Cardiology, 33(4). https://doi.org/10.1002/clc.20615

Statin therapy in patients with diastolic heart failure. / Tehrani, Faramarz; Morrissey, Ryan; Phan, Anita; Chien, Christopher; Schwarz, Ernst R.

In: Clinical Cardiology, Vol. 33, No. 4, 04.2010.

Research output: Contribution to journalArticle

Tehrani, F, Morrissey, R, Phan, A, Chien, C & Schwarz, ER 2010, 'Statin therapy in patients with diastolic heart failure', Clinical Cardiology, vol. 33, no. 4. https://doi.org/10.1002/clc.20615
Tehrani F, Morrissey R, Phan A, Chien C, Schwarz ER. Statin therapy in patients with diastolic heart failure. Clinical Cardiology. 2010 Apr;33(4). https://doi.org/10.1002/clc.20615
Tehrani, Faramarz ; Morrissey, Ryan ; Phan, Anita ; Chien, Christopher ; Schwarz, Ernst R. / Statin therapy in patients with diastolic heart failure. In: Clinical Cardiology. 2010 ; Vol. 33, No. 4.
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abstract = "Background: There is controversy regarding the potentialeffects of statintherapy onmortality in patientswith heart failure. The present study analyzed the possible effects of statin therapy on morbidity and mortality in patientswith diastolic heart failure over long-termfollow-up. Hypothesis: To evaluate potential effect of statin therapy on hospitalization rate andmortality in patientswith diastolic heart failure. Methods: Patientswith preserved left ventricular ejection fraction (≥50{\%}), hospitalized for clinical symptoms of heart failure were evaluated. Patients on statin therapy started at or prior to their first heart failure admission representedgroup 1 and patientswithout statin therapy representedgroup 2. The effects of statins on hospitalization rates and mortality were assessed during a 5 year follow-up. Results: A total of 270 patients (group 1 n = 81; group 2 n = 189) were followed over 5 years. Patients on statinsdemonstratedimproved survival compared to patientswithout statintherapy (hazard ratio [HR]=0.65, 95{\%} confidence interval [CI]: 0.45-0.95, P = .029). The survival benefit was maintained after adjusting for differences in baseline characteristics, comorbidities, and other medications. There was no significant difference in the mean cardiovascular hospitalization rate (3.0 ± 3.2 vs 3.8 ± 4.7, P = .23) and in overall hospitalization rate (7.1 ± 6.3 vs 7.8 ± 7.7, P = .52) between groups 1 and 2, respectively. Conclusion: Statin therapy appears to be associated with improved survival in patients with diastolic heart failure.",
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