TY - JOUR
T1 - State of the Science in Deceased Organ Donor Management
AU - Patel, Madhukar S.
AU - Sally, Mitchell
AU - Niemann, Claus U.
AU - Malinoski, Darren J.
N1 - Publisher Copyright:
© 2018, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Purpose of Review: Research in deceased organ donor management offers an opportunity to increase the quantity and quality of organs available for transplantation. This article aims to appraise the current literature with a focus on reviewing deceased donor intervention trials. Recent Findings: Aggressive critical care management after determination of brain death resulting in meeting of a donor management goal bundle has consistently demonstrated an association with significantly more organs transplanted per donor as well as improved graft outcomes. Although there is a dearth of experience with randomized donor intervention studies, dopamine and targeted mild therapeutic hypothermia have been found to significantly reduce delayed graft function in kidney recipients. Summary: Progress in understanding the ethical, legal, regulatory, policy, and organizational elements of organ donor research has provided a mechanism that allows for the endorsement of potentially impactful donor management studies. Ongoing trials should incorporate methods to ensure safety to all organs donated from donors enrolled in interventional trials.
AB - Purpose of Review: Research in deceased organ donor management offers an opportunity to increase the quantity and quality of organs available for transplantation. This article aims to appraise the current literature with a focus on reviewing deceased donor intervention trials. Recent Findings: Aggressive critical care management after determination of brain death resulting in meeting of a donor management goal bundle has consistently demonstrated an association with significantly more organs transplanted per donor as well as improved graft outcomes. Although there is a dearth of experience with randomized donor intervention studies, dopamine and targeted mild therapeutic hypothermia have been found to significantly reduce delayed graft function in kidney recipients. Summary: Progress in understanding the ethical, legal, regulatory, policy, and organizational elements of organ donor research has provided a mechanism that allows for the endorsement of potentially impactful donor management studies. Ongoing trials should incorporate methods to ensure safety to all organs donated from donors enrolled in interventional trials.
KW - Deceased organ donor
KW - Donor intervention research
KW - Organ donor clinical trial
KW - Organ donor management
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U2 - 10.1007/s40472-018-0207-8
DO - 10.1007/s40472-018-0207-8
M3 - Review article
AN - SCOPUS:85090081457
SN - 2196-3029
VL - 5
SP - 273
EP - 281
JO - Current Transplantation Reports
JF - Current Transplantation Reports
IS - 4
ER -