Standard fractionation external beam radiotherapy with and without intraoperative radiotherapy for locally recurrent rectal cancer: The role of local therapy in patients with a high competing risk of death from distant disease

Amar U. Kishan, Justin C. Voog, Jonathan Wiseman, Ryan R. Cook, Marek Ancukiewicz, Percy Lee, David P. Ryan, Jeffrey W. Clark, David L. Berger, James C. Cusack, Jennifer Y. Wo, Theodore S. Hong

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective: We sought to evaluate the effectiveness and safety of utilizing radiotherapy (RT) with standard fractionation, with or without intraoperative RT (IORT), to treat locally recurrent rectal cancer (LRRC). Methods: Retrospective review of 25 patients with LRRC treated with standard fractionation RT from 2005 to 2011. 15 patients (60%) had prior pelvic RT and 10 (40%) had synchronous metastases. The median equivalent dose in 2-Gy fractions was 30 and 49.6Gy in patients with and without prior RT, respectively. 23 patients (92%) received concurrent chemotherapy and 16 (64%) underwent surgical resection. Eight patients (33.3%, four with and four without prior RT) received IORT. A competing risks model was developed to estimate the cumulative incidence of local failure with death treated as a competing event. Results: Median follow-up was 36.9 months after the date of local recurrence. 3-year rates of overall survival (OS), local control (LC) and death with LC were 51.6%, 73.3% and 69.2%, respectively. On multivariable analysis, surgical resection was significantly predictive of improved OS (p<0.05). If surgical resection were removed from the multivariable model, given the collinearity between IORT delivery and surgical resection, then IORT also became a significant predictor of OS (p<0.05). Systemic disease at the time of local recurrence was not associated with either LC or OS. No patient had grade ≥3 acute or late toxicity. Conclusion: RT with standard fractionation is safe and effective in the treatment of patients with LRRC, even in patients with significant risk of systemic disease and/or history of prior RT. Advances in knowledge: The utility of RT with standard fractionation, generally with chemotherapy, in the treatment of LRRC is demonstrated. In this high-risk cohort of patients with a 40% incidence of synchronous metastatic disease, surgical resection of the recurrence was the major predictor of OS, though a benefit to IORT was also suggested. No patients had grade ≥3 acute or late toxicity, though 40% had undergone prior RT, underscoring the tolerability of standard fractionation RT in this setting.

Original languageEnglish (US)
Article number20170134
JournalBritish Journal of Radiology
Volume90
Issue number1076
DOIs
StatePublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Standard fractionation external beam radiotherapy with and without intraoperative radiotherapy for locally recurrent rectal cancer: The role of local therapy in patients with a high competing risk of death from distant disease'. Together they form a unique fingerprint.

Cite this