Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Bart C. Jongbloets, Suzanne Lemstra, Roberta Schellino, Mark H. Broekhoven, Jyoti Parkash, Anita J C G M Hellemons, Tianyi Mao, Paolo Giacobini, Henriette Van Praag, Silvia De Marchis, Geert M J Ramakers, R. Jeroen Pasterkamp

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively expressed in early neural progenitors in the adult mouse DG and mediates the inhibitory effects of Sema7A on progenitor proliferation. Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexity and spine development through β1-subunit-containing integrin receptors. Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of guidance cues in the adult brain.

Original languageEnglish (US)
Article number14666
JournalNature Communications
Volume8
DOIs
StatePublished - Mar 10 2017

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Neurogenesis
Dentate Gyrus
Brain
brain
Parahippocampal Gyrus
Immune system
Cell Surface Receptors
Neurology
Dendrites
Integrins
Nervous System
Cues
Immune System
Spine
nervous system
immune systems
spine
regulators
cues
dendrites

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Jongbloets, B. C., Lemstra, S., Schellino, R., Broekhoven, M. H., Parkash, J., Hellemons, A. J. C. G. M., ... Pasterkamp, R. J. (2017). Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nature Communications, 8, [14666]. https://doi.org/10.1038/ncomms14666

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. / Jongbloets, Bart C.; Lemstra, Suzanne; Schellino, Roberta; Broekhoven, Mark H.; Parkash, Jyoti; Hellemons, Anita J C G M; Mao, Tianyi; Giacobini, Paolo; Van Praag, Henriette; De Marchis, Silvia; Ramakers, Geert M J; Pasterkamp, R. Jeroen.

In: Nature Communications, Vol. 8, 14666, 10.03.2017.

Research output: Contribution to journalArticle

Jongbloets, BC, Lemstra, S, Schellino, R, Broekhoven, MH, Parkash, J, Hellemons, AJCGM, Mao, T, Giacobini, P, Van Praag, H, De Marchis, S, Ramakers, GMJ & Pasterkamp, RJ 2017, 'Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors', Nature Communications, vol. 8, 14666. https://doi.org/10.1038/ncomms14666
Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJCGM et al. Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nature Communications. 2017 Mar 10;8. 14666. https://doi.org/10.1038/ncomms14666
Jongbloets, Bart C. ; Lemstra, Suzanne ; Schellino, Roberta ; Broekhoven, Mark H. ; Parkash, Jyoti ; Hellemons, Anita J C G M ; Mao, Tianyi ; Giacobini, Paolo ; Van Praag, Henriette ; De Marchis, Silvia ; Ramakers, Geert M J ; Pasterkamp, R. Jeroen. / Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. In: Nature Communications. 2017 ; Vol. 8.
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abstract = "The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively expressed in early neural progenitors in the adult mouse DG and mediates the inhibitory effects of Sema7A on progenitor proliferation. Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexity and spine development through β1-subunit-containing integrin receptors. Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of guidance cues in the adult brain.",
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