Stage II endometrial carcinoma treated with external-beam radiotherapy, intracavitary application of cesium, and surgery

Edward S. Podczaski, Paul Kaminski, Alberto Manetta, Douglas Louk, Charles Andrews, James Larson, Koenraad De Geest, Rodrigue Mortel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

From September 1972 to September 1987, thirty-six patients with stage II carcinoma of the endometrium were treated with external-beam radiotherapy to the pelvis, a single intracavitary application of cesium-137, and extrafascial hysterectomy with adnexectomy. Patients were followed for a median of 54.4 months. Overall 2- and 5-year actuarial survival rates were 83 and 58%, respectively. Survival was analyzed in terms of the independent variables surgical stage, presence of a gross cervical lesion, and residual disease within the myometrium or cervix. Factors contribuing to patients survival were analyzed by the log-rank method. The 12 patients with a gross cervical lesion had an adverse prognosis, as compared to those without such a lesion (P <0.05). Seven of the twelve patients (58%) with a cervical lesion at clinical staging demonstrated persistent or recurrent disease. The presence of extrauterine disease at surgery was a major prognostic factor in patient survival (P <0.01). All six patients with extrauterine disease expired 2.3 to 53.0 months after hysterectomy. Two patients with persistence of disease expired 2.3 and 7.5 months after hysterectomy. Eleven patients developed recurrent disease 2.1 to 56.5 months after hysterectomy. All presented with distant metastases. Four of the thirteen patients with persistent or recurrent disease had no residual tumor within the myometrium.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalGynecologic Oncology
Volume35
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Cesium
Endometrial Neoplasms
Radiotherapy
Hysterectomy
Myometrium
Survival
Residual Neoplasm
Pelvis
Cervix Uteri
Survival Rate
Neoplasm Metastasis

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Podczaski, E. S., Kaminski, P., Manetta, A., Louk, D., Andrews, C., Larson, J., ... Mortel, R. (1989). Stage II endometrial carcinoma treated with external-beam radiotherapy, intracavitary application of cesium, and surgery. Gynecologic Oncology, 35(2), 251-254. https://doi.org/10.1016/0090-8258(89)90054-1

Stage II endometrial carcinoma treated with external-beam radiotherapy, intracavitary application of cesium, and surgery. / Podczaski, Edward S.; Kaminski, Paul; Manetta, Alberto; Louk, Douglas; Andrews, Charles; Larson, James; De Geest, Koenraad; Mortel, Rodrigue.

In: Gynecologic Oncology, Vol. 35, No. 2, 1989, p. 251-254.

Research output: Contribution to journalArticle

Podczaski, Edward S. ; Kaminski, Paul ; Manetta, Alberto ; Louk, Douglas ; Andrews, Charles ; Larson, James ; De Geest, Koenraad ; Mortel, Rodrigue. / Stage II endometrial carcinoma treated with external-beam radiotherapy, intracavitary application of cesium, and surgery. In: Gynecologic Oncology. 1989 ; Vol. 35, No. 2. pp. 251-254.
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