Stable neurological function in subjects treated with 2'3'dideoxyinosine

J. J. Sidtis; U. Dafni; Peter Slasor; C. Hall; R. W. Price; K. Kieburtz; T. Tucker; D. B. Clifford

doi:10.3109/13550289709018299

Stable neurological function in subjects treated with 2'3'dideoxyinosine

J. J. Sidtis, U. Dafni, Peter Slasor, C. Hall, R. W. Price, K. Kieburtz, T. Tucker, D. B. Clifford

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine (ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neurologic side effects, but also for their relative efficacy to ZDV in the prevention of ADC. The present study reports the effects of 2'3'dideoxyinosine (DDI, didanosine, Videx) therapy on neuropsychological performance in the context of several large clinical trials targeting advanced systemic HIV-1 infection. Subjects treated with DDI had stable neurologic performance in quantitative tests over a 1 year period and were similar to zidovudine treated subjects.

Original language	English (US)
Pages (from-to)	233-240
Number of pages	8
Journal	Journal of neurovirology
Volume	3
Issue number	3
DOIs	https://doi.org/10.3109/13550289709018299
State	Published - Jun 1997
Externally published	Yes

Keywords

AIDS dementia
Acquired immunodeficiency syndrome
DDI
Didanosine
HIV
Zidovudine

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.3109/13550289709018299

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title = "Stable neurological function in subjects treated with 2'3'dideoxyinosine",

abstract = "AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine (ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neurologic side effects, but also for their relative efficacy to ZDV in the prevention of ADC. The present study reports the effects of 2'3'dideoxyinosine (DDI, didanosine, Videx) therapy on neuropsychological performance in the context of several large clinical trials targeting advanced systemic HIV-1 infection. Subjects treated with DDI had stable neurologic performance in quantitative tests over a 1 year period and were similar to zidovudine treated subjects.",

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AU - Sidtis, J. J.

AU - Dafni, U.

AU - Slasor, Peter

AU - Hall, C.

AU - Price, R. W.

AU - Kieburtz, K.

AU - Tucker, T.

AU - Clifford, D. B.

PY - 1997/6

Y1 - 1997/6

N2 - AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine (ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neurologic side effects, but also for their relative efficacy to ZDV in the prevention of ADC. The present study reports the effects of 2'3'dideoxyinosine (DDI, didanosine, Videx) therapy on neuropsychological performance in the context of several large clinical trials targeting advanced systemic HIV-1 infection. Subjects treated with DDI had stable neurologic performance in quantitative tests over a 1 year period and were similar to zidovudine treated subjects.

AB - AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine (ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neurologic side effects, but also for their relative efficacy to ZDV in the prevention of ADC. The present study reports the effects of 2'3'dideoxyinosine (DDI, didanosine, Videx) therapy on neuropsychological performance in the context of several large clinical trials targeting advanced systemic HIV-1 infection. Subjects treated with DDI had stable neurologic performance in quantitative tests over a 1 year period and were similar to zidovudine treated subjects.

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KW - Acquired immunodeficiency syndrome

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KW - Didanosine

KW - HIV

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Stable neurological function in subjects treated with 2'3'dideoxyinosine

Abstract

Keywords

ASJC Scopus subject areas

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