Stable Long-Term Pulmonary Function after Myeloablative Double Cord Blood Transplant

Filippo Milano, Jason W. Chien, Ivy Riffkin, Jonathan A. Gutman, Laura Newell, Steven A. Pergam, Colleen Delaney

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Pulmonary dysfunction has been well described after myeloablative transplantation with conventional allogeneic donors; however, whether the risk is similar after alternative donor transplantation with cord blood as the stem cell source has not yet been investigated. We performed a retrospective analysis of patients who underwent double cord blood transplantation after myeloablative conditioning. Pulmonary function tests were performed pretransplantation and at day 80, 1 year, and 2 years posttransplantation, with 56 patients included in the final analysis. No significant change from baseline with respect to the mean values and mean change in pulmonary function test values were observed at 1 year posttransplantation. The rate of lung function decline from baseline to 1 year posttransplantation was <5% in 75% patients; mildly abnormal lung function was reported in 58% of the patients. The cumulative incidence of noninfectious pulmonary complications was 9.7%. Future prospective studies are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalBiology of Blood and Marrow Transplantation
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2012

    Fingerprint

Keywords

  • Lung function
  • Pulmonary complications
  • Umbilical cord blood transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this