St. John: Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein

Heather Norvelle, Ines Koerner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses the pharmacokinetic interaction between cyclosporine and St. John's wort, resulting in renal failure. Cylcosporin is a cytochrome P450 3A4 and P-glycoprotein substrate and St. John's wort is a 3A4 and P-glycoprotein inducer.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages969-971
Number of pages3
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

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Hypericum
Cytochrome P-450 CYP3A
P-Glycoprotein
Cyclosporine
Renal Insufficiency
Pharmacokinetics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Norvelle, H., & Koerner, I. (2015). St. John: Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 969-971). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_219

St. John : Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein. / Norvelle, Heather; Koerner, Ines.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 969-971.

Research output: Chapter in Book/Report/Conference proceedingChapter

Norvelle, H & Koerner, I 2015, St. John: Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 969-971. https://doi.org/10.1007/978-1-4614-7495-1_219
Norvelle H, Koerner I. St. John: Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 969-971 https://doi.org/10.1007/978-1-4614-7495-1_219
Norvelle, Heather ; Koerner, Ines. / St. John : Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 969-971
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