SRC family kinases in cell volume regulation

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion - transport has been recognized for several years. Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease. In addition, members of this tyrosine kinase family participate in the mechanotrans-duction that accompanies cell membrane deformation. Finally, at least one SRC family member operates in concert with the p38 MAPK to regulate tonicity-dependent gene transcription.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Cell Physiology
Volume288
Issue number3 57-3
DOIs
StatePublished - Mar 2005

Fingerprint

Osmotic Pressure
Cell Size
Protein-Tyrosine Kinases
Phosphotransferases
Aptitude
Ion Transport
p38 Mitogen-Activated Protein Kinases
Transcription
Cell membranes
Mountings
Genes
Cell Membrane
Ions
Tissue

Keywords

  • Hypertonicity
  • Hypotonicity
  • Ion transport
  • Transient receptor potential
  • Tyrosine kinase

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

SRC family kinases in cell volume regulation. / Cohen, David.

In: American Journal of Physiology - Cell Physiology, Vol. 288, No. 3 57-3, 03.2005.

Research output: Contribution to journalArticle

@article{97fadd65376b47368d936211a3a6c6a9,
title = "SRC family kinases in cell volume regulation",
abstract = "SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion - transport has been recognized for several years. Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease. In addition, members of this tyrosine kinase family participate in the mechanotrans-duction that accompanies cell membrane deformation. Finally, at least one SRC family member operates in concert with the p38 MAPK to regulate tonicity-dependent gene transcription.",
keywords = "Hypertonicity, Hypotonicity, Ion transport, Transient receptor potential, Tyrosine kinase",
author = "David Cohen",
year = "2005",
month = "3",
doi = "10.1152/ajpcell.00452.2004",
language = "English (US)",
volume = "288",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "3 57-3",

}

TY - JOUR

T1 - SRC family kinases in cell volume regulation

AU - Cohen, David

PY - 2005/3

Y1 - 2005/3

N2 - SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion - transport has been recognized for several years. Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease. In addition, members of this tyrosine kinase family participate in the mechanotrans-duction that accompanies cell membrane deformation. Finally, at least one SRC family member operates in concert with the p38 MAPK to regulate tonicity-dependent gene transcription.

AB - SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion - transport has been recognized for several years. Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease. In addition, members of this tyrosine kinase family participate in the mechanotrans-duction that accompanies cell membrane deformation. Finally, at least one SRC family member operates in concert with the p38 MAPK to regulate tonicity-dependent gene transcription.

KW - Hypertonicity

KW - Hypotonicity

KW - Ion transport

KW - Transient receptor potential

KW - Tyrosine kinase

UR - http://www.scopus.com/inward/record.url?scp=13644252212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13644252212&partnerID=8YFLogxK

U2 - 10.1152/ajpcell.00452.2004

DO - 10.1152/ajpcell.00452.2004

M3 - Article

VL - 288

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 3 57-3

ER -