Squamous cell carcinoma of buccal mucosa: A 40-year review

Adam Deconde, Mia E. Miller, Beth Palla, Chi Lai, David Elashoff, Dinesh Chhetri, Maie A. St. John

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The aim of this study was to analyze the outcome of surgical therapy for buccal squamous cell carcinoma (SCCA) at a single tertiary care institution during a 40-year period. Materials and methods: A retrospective review was performed by examining the records and pathology of 48 patients with buccal SCCA treated at a single tertiary care institution from 1970 to 2009. Results: Treatment entailed surgery alone in 18 patients (37.5%) and surgery followed by radiation therapy in 30 patients (62.5%). Composite resection was performed in 17 patients (35.4%), and ipsilateral neck dissections were performed in 37patients (77.1%). One-year observed actuarial disease-free survival rates were 60%, 46%, 0%, and 40% for T1 through T4, respectively. Univariate analysis revealed increased age as a risk factor for disease recurrence (P =.062), with skin taken and neck dissection not achieving significance (P =.24 and.20, respectively). Multivariate analysis demonstrated age as increasing risk and neck dissection as decreasing risk of recurrence (P =.029 and.023, respectively). Conclusions: We report relatively high disease-free survival rates in patients who underwent aggressive resection and neck dissection. Performance of neck dissection and younger age were associated with a favorable prognosis. Performance of neck dissection may decrease the risk of recurrence in primary SCCA of the buccal mucosa. Although through-and-through resection of skin decreased risk of disease recurrence, this difference is not statistically significant (P =.24).

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume33
Issue number6
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Neck Dissection
Mouth Mucosa
Squamous Cell Carcinoma
Recurrence
Cheek
Tertiary Healthcare
Disease-Free Survival
Survival Rate
Skin
Radiotherapy
Multivariate Analysis
Pathology
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Deconde, A., Miller, M. E., Palla, B., Lai, C., Elashoff, D., Chhetri, D., & St. John, M. A. (2012). Squamous cell carcinoma of buccal mucosa: A 40-year review. American Journal of Otolaryngology - Head and Neck Medicine and Surgery, 33(6), 673-677. https://doi.org/10.1016/j.amjoto.2012.04.006

Squamous cell carcinoma of buccal mucosa : A 40-year review. / Deconde, Adam; Miller, Mia E.; Palla, Beth; Lai, Chi; Elashoff, David; Chhetri, Dinesh; St. John, Maie A.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 33, No. 6, 11.2012, p. 673-677.

Research output: Contribution to journalArticle

Deconde, A, Miller, ME, Palla, B, Lai, C, Elashoff, D, Chhetri, D & St. John, MA 2012, 'Squamous cell carcinoma of buccal mucosa: A 40-year review', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 33, no. 6, pp. 673-677. https://doi.org/10.1016/j.amjoto.2012.04.006
Deconde, Adam ; Miller, Mia E. ; Palla, Beth ; Lai, Chi ; Elashoff, David ; Chhetri, Dinesh ; St. John, Maie A. / Squamous cell carcinoma of buccal mucosa : A 40-year review. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2012 ; Vol. 33, No. 6. pp. 673-677.
@article{33c6df45c56549e4906e1b64785946c5,
title = "Squamous cell carcinoma of buccal mucosa: A 40-year review",
abstract = "Purpose: The aim of this study was to analyze the outcome of surgical therapy for buccal squamous cell carcinoma (SCCA) at a single tertiary care institution during a 40-year period. Materials and methods: A retrospective review was performed by examining the records and pathology of 48 patients with buccal SCCA treated at a single tertiary care institution from 1970 to 2009. Results: Treatment entailed surgery alone in 18 patients (37.5{\%}) and surgery followed by radiation therapy in 30 patients (62.5{\%}). Composite resection was performed in 17 patients (35.4{\%}), and ipsilateral neck dissections were performed in 37patients (77.1{\%}). One-year observed actuarial disease-free survival rates were 60{\%}, 46{\%}, 0{\%}, and 40{\%} for T1 through T4, respectively. Univariate analysis revealed increased age as a risk factor for disease recurrence (P =.062), with skin taken and neck dissection not achieving significance (P =.24 and.20, respectively). Multivariate analysis demonstrated age as increasing risk and neck dissection as decreasing risk of recurrence (P =.029 and.023, respectively). Conclusions: We report relatively high disease-free survival rates in patients who underwent aggressive resection and neck dissection. Performance of neck dissection and younger age were associated with a favorable prognosis. Performance of neck dissection may decrease the risk of recurrence in primary SCCA of the buccal mucosa. Although through-and-through resection of skin decreased risk of disease recurrence, this difference is not statistically significant (P =.24).",
author = "Adam Deconde and Miller, {Mia E.} and Beth Palla and Chi Lai and David Elashoff and Dinesh Chhetri and {St. John}, {Maie A.}",
year = "2012",
month = "11",
doi = "10.1016/j.amjoto.2012.04.006",
language = "English (US)",
volume = "33",
pages = "673--677",
journal = "American Journal of Otolaryngology - Head and Neck Medicine and Surgery",
issn = "0196-0709",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Squamous cell carcinoma of buccal mucosa

T2 - A 40-year review

AU - Deconde, Adam

AU - Miller, Mia E.

AU - Palla, Beth

AU - Lai, Chi

AU - Elashoff, David

AU - Chhetri, Dinesh

AU - St. John, Maie A.

PY - 2012/11

Y1 - 2012/11

N2 - Purpose: The aim of this study was to analyze the outcome of surgical therapy for buccal squamous cell carcinoma (SCCA) at a single tertiary care institution during a 40-year period. Materials and methods: A retrospective review was performed by examining the records and pathology of 48 patients with buccal SCCA treated at a single tertiary care institution from 1970 to 2009. Results: Treatment entailed surgery alone in 18 patients (37.5%) and surgery followed by radiation therapy in 30 patients (62.5%). Composite resection was performed in 17 patients (35.4%), and ipsilateral neck dissections were performed in 37patients (77.1%). One-year observed actuarial disease-free survival rates were 60%, 46%, 0%, and 40% for T1 through T4, respectively. Univariate analysis revealed increased age as a risk factor for disease recurrence (P =.062), with skin taken and neck dissection not achieving significance (P =.24 and.20, respectively). Multivariate analysis demonstrated age as increasing risk and neck dissection as decreasing risk of recurrence (P =.029 and.023, respectively). Conclusions: We report relatively high disease-free survival rates in patients who underwent aggressive resection and neck dissection. Performance of neck dissection and younger age were associated with a favorable prognosis. Performance of neck dissection may decrease the risk of recurrence in primary SCCA of the buccal mucosa. Although through-and-through resection of skin decreased risk of disease recurrence, this difference is not statistically significant (P =.24).

AB - Purpose: The aim of this study was to analyze the outcome of surgical therapy for buccal squamous cell carcinoma (SCCA) at a single tertiary care institution during a 40-year period. Materials and methods: A retrospective review was performed by examining the records and pathology of 48 patients with buccal SCCA treated at a single tertiary care institution from 1970 to 2009. Results: Treatment entailed surgery alone in 18 patients (37.5%) and surgery followed by radiation therapy in 30 patients (62.5%). Composite resection was performed in 17 patients (35.4%), and ipsilateral neck dissections were performed in 37patients (77.1%). One-year observed actuarial disease-free survival rates were 60%, 46%, 0%, and 40% for T1 through T4, respectively. Univariate analysis revealed increased age as a risk factor for disease recurrence (P =.062), with skin taken and neck dissection not achieving significance (P =.24 and.20, respectively). Multivariate analysis demonstrated age as increasing risk and neck dissection as decreasing risk of recurrence (P =.029 and.023, respectively). Conclusions: We report relatively high disease-free survival rates in patients who underwent aggressive resection and neck dissection. Performance of neck dissection and younger age were associated with a favorable prognosis. Performance of neck dissection may decrease the risk of recurrence in primary SCCA of the buccal mucosa. Although through-and-through resection of skin decreased risk of disease recurrence, this difference is not statistically significant (P =.24).

UR - http://www.scopus.com/inward/record.url?scp=84868349559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868349559&partnerID=8YFLogxK

U2 - 10.1016/j.amjoto.2012.04.006

DO - 10.1016/j.amjoto.2012.04.006

M3 - Article

C2 - 22681929

AN - SCOPUS:84868349559

VL - 33

SP - 673

EP - 677

JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

SN - 0196-0709

IS - 6

ER -