Squamous and basal cell carcinoma in heart transplant recipients

T. D. Lampros, A. Cobanoglu, Frank Parker, R. Ratkovec, Douglas Norman, R. Hershberger

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Background: Cutaneous malignancies are frequent in organ transplant recipients. We retrospectively reviewed a large series of heart transplant recipients and report on the prevalence and risk factors for development of cutaneous squamous and basal cell carcinoma. Methods: Between Dec. 4, 1985, and Dec. 27, 1996, 299 heart transplantations were performed at the Oregon Health Sciences University. Heart transplant recipients with more than 6 months survival or follow-up were investigated for squamous and basal cell carcinoma (n = 248). Results: Forty-one patients (17%) were found to have 192 squamous or basal cell carcinomas. Squamous cell carcinoma was the predominate skin malignancy, constituting 172 (90%) of the lesions. The mean number of skin malignancies per patient was 4.7 ± 0.81 (range 125). Patients with development of a skin malignancy were 8 years older on average, with a male-to female ratio of 19.5:1. The predominant skin type and eye color were fair (59%) and blue (59%), respectively. Cumulative risk, based on actuarial survival analysis for development of a squamous or basal cell carcinoma at 1 year, was 3% and increased to 21% and 35% at 5 and 10 years, respectively. In addition, cumulative risk increased in patients who received treatment with OKT3. Conclusion: Cumulative risk of development of a skin malignancy increased with time and use of OKT3. Additional patient risk factors included older age, male sex, fair skin, and blue eyes.

Original languageEnglish (US)
Pages (from-to)586-591
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume17
Issue number6
StatePublished - 1998

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Basal Cell Carcinoma
Squamous Cell Carcinoma
Skin
Muromonab-CD3
Neoplasms
Actuarial Analysis
Eye Color
Skin Pigmentation
Heart Transplantation
Survival Analysis
Transplant Recipients
Transplants
Survival
Health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Lampros, T. D., Cobanoglu, A., Parker, F., Ratkovec, R., Norman, D., & Hershberger, R. (1998). Squamous and basal cell carcinoma in heart transplant recipients. Journal of Heart and Lung Transplantation, 17(6), 586-591.

Squamous and basal cell carcinoma in heart transplant recipients. / Lampros, T. D.; Cobanoglu, A.; Parker, Frank; Ratkovec, R.; Norman, Douglas; Hershberger, R.

In: Journal of Heart and Lung Transplantation, Vol. 17, No. 6, 1998, p. 586-591.

Research output: Contribution to journalArticle

Lampros, TD, Cobanoglu, A, Parker, F, Ratkovec, R, Norman, D & Hershberger, R 1998, 'Squamous and basal cell carcinoma in heart transplant recipients', Journal of Heart and Lung Transplantation, vol. 17, no. 6, pp. 586-591.
Lampros, T. D. ; Cobanoglu, A. ; Parker, Frank ; Ratkovec, R. ; Norman, Douglas ; Hershberger, R. / Squamous and basal cell carcinoma in heart transplant recipients. In: Journal of Heart and Lung Transplantation. 1998 ; Vol. 17, No. 6. pp. 586-591.
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