Spontaneous echo contrast and hemorheologic abnormalities in cerebrovascular disease

Dennis P. Briley, George Giraud, Nancy B. Beamer, Eugene M. Spear, Susan E. Grauer, James Edwards, Wayne Clark, Gary J. Sexton, Bruce M. Coull

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background and Purpose Spontaneous echo contrast (SEC) is thought to represent a risk factor for cardioembolic stroke. In vitro studies suggest that SEC results from interaction between red cells and fibrinogen. To better understand the relation between SEC and stroke and to investigate the in vivo genesis of SEC, we examined the relation between SEC, the constituents of the blood, and plasma and serum viscosity in patients with acute stroke or chronic cerebrovascular disease. Methods Fifty patients with acute stroke or chronic cerebrovascular disease referred for transesophageal echocardiogram (TEE) were studied by transthoracic echocardiography and TEE. Complete blood count, fibrinogen, albumin, -γ-globulin, and plasma and serum viscosity determinations were made. Left atrial SEC was graded as absent, mild, or marked by means of TEE. Results SEC was absent in 31 patients, mild in 10 patients, and marked in 9 patients. Higher grade of SEC was associated with a significantly greater percentage of patients with atrial fibrillation and larger left atrial dimension. Atrial fibrillation was present in 23% of the patients in the SEC absent group, 50% of the patients in the mild SEC group, and 78% of the patients in the marked SEC group (P

Original languageEnglish (US)
Pages (from-to)1564-1569
Number of pages6
JournalStroke
Volume25
Issue number8
StatePublished - 1994

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Cerebrovascular Disorders
Stroke
Viscosity
Serum Albumin
Fibrinogen
Atrial Fibrillation
Chronic Disease
Serum Globulins
Blood Cell Count
Echocardiography

Keywords

  • Cardioembolic stroke
  • Echocardiography
  • Erythrocytes
  • Fibrinogen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Briley, D. P., Giraud, G., Beamer, N. B., Spear, E. M., Grauer, S. E., Edwards, J., ... Coull, B. M. (1994). Spontaneous echo contrast and hemorheologic abnormalities in cerebrovascular disease. Stroke, 25(8), 1564-1569.

Spontaneous echo contrast and hemorheologic abnormalities in cerebrovascular disease. / Briley, Dennis P.; Giraud, George; Beamer, Nancy B.; Spear, Eugene M.; Grauer, Susan E.; Edwards, James; Clark, Wayne; Sexton, Gary J.; Coull, Bruce M.

In: Stroke, Vol. 25, No. 8, 1994, p. 1564-1569.

Research output: Contribution to journalArticle

Briley, DP, Giraud, G, Beamer, NB, Spear, EM, Grauer, SE, Edwards, J, Clark, W, Sexton, GJ & Coull, BM 1994, 'Spontaneous echo contrast and hemorheologic abnormalities in cerebrovascular disease', Stroke, vol. 25, no. 8, pp. 1564-1569.
Briley DP, Giraud G, Beamer NB, Spear EM, Grauer SE, Edwards J et al. Spontaneous echo contrast and hemorheologic abnormalities in cerebrovascular disease. Stroke. 1994;25(8):1564-1569.
Briley, Dennis P. ; Giraud, George ; Beamer, Nancy B. ; Spear, Eugene M. ; Grauer, Susan E. ; Edwards, James ; Clark, Wayne ; Sexton, Gary J. ; Coull, Bruce M. / Spontaneous echo contrast and hemorheologic abnormalities in cerebrovascular disease. In: Stroke. 1994 ; Vol. 25, No. 8. pp. 1564-1569.
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AU - Giraud, George

AU - Beamer, Nancy B.

AU - Spear, Eugene M.

AU - Grauer, Susan E.

AU - Edwards, James

AU - Clark, Wayne

AU - Sexton, Gary J.

AU - Coull, Bruce M.

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