Split-spectrum phase-gradient optical coherence tomography angiography

Gangjun Liu, Yali Jia, Alex D. Pechauer, Rahul Chandwani, David Huang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A phase gradient angiography (PGA) method is proposed for optical coherence tomography (OCT). This method allows the use of phase information to map the microvasculature in tissue without the correction of bulk motion and laser trigger jitter induced phase artifacts. PGA can also be combined with the amplitude/intensity to improve the performance. Split-spectrum technique can further increase the signal to noise ratio by more than two times. In-vivo imaging of human retinal circulation is shown with a 70 kHz, 840 nm spectral domain OCT system and a 200 kHz, 1050 nm swept source OCT system. Four different OCT angiography methods are compared. The best performance was achieved with split-spectrum amplitude and phase-gradient angiography.

Original languageEnglish (US)
Pages (from-to)2943-2954
Number of pages12
JournalBiomedical Optics Express
Issue number8
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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