Split-spectrum phase-gradient optical coherence tomography angiography

Gangjun Liu, Jia Yali, Alex D. Pechauer, Rahul Chandwani, David Huang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A phase gradient angiography (PGA) method is proposed for optical coherence tomography (OCT). This method allows the use of phase information to map the microvasculature in tissue without the correction of bulk motion and laser trigger jitter induced phase artifacts. PGA can also be combined with the amplitude/intensity to improve the performance. Split-spectrum technique can further increase the signal to noise ratio by more than two times. In-vivo imaging of human retinal circulation is shown with a 70 kHz, 840 nm spectral domain OCT system and a 200 kHz, 1050 nm swept source OCT system. Four different OCT angiography methods are compared. The best performance was achieved with split-spectrum amplitude and phase-gradient angiography.

Original languageEnglish (US)
Pages (from-to)2943-2954
Number of pages12
JournalBiomedical Optics Express
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2016

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angiography
Optical Coherence Tomography
Angiography
tomography
gradients
Signal-To-Noise Ratio
Microvessels
Artifacts
artifacts
Lasers
signal to noise ratios
actuators
vibration
lasers

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Split-spectrum phase-gradient optical coherence tomography angiography. / Liu, Gangjun; Yali, Jia; Pechauer, Alex D.; Chandwani, Rahul; Huang, David.

In: Biomedical Optics Express, Vol. 7, No. 8, 01.08.2016, p. 2943-2954.

Research output: Contribution to journalArticle

Liu, Gangjun ; Yali, Jia ; Pechauer, Alex D. ; Chandwani, Rahul ; Huang, David. / Split-spectrum phase-gradient optical coherence tomography angiography. In: Biomedical Optics Express. 2016 ; Vol. 7, No. 8. pp. 2943-2954.
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