Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia

C. Spiro, B. C. Gliniak, D. Kabat

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Interleukin-3-dependent hematopoietic stem cells commonly accumulate in spleens of mice infected with leukemia viruses. To study their origins, a molecularly tagged helper-free Friend spleen focus-forming virus was used to produce erythroleukemias. Uninfected interleukin-3-dependent basophil-mast cell progenitors coproliferated amidst the spleen focus-forming virus-infected leukemic cells. Splenic proliferation of normal stem cells is apparently a host response to leukemogenesis, and we propose that it may contribute to certain retroviral diseases.

Original languageEnglish (US)
Pages (from-to)4434-4437
Number of pages4
JournalJournal of virology
Volume63
Issue number10
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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