Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia

C. Spiro, B. C. Gliniak, David Kabat

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Interleukin-3-dependent hematopoietic stem cells commonly accumulate in spleens of mice infected with leukemia viruses. To study their origins, a molecularly tagged helper-free Friend spleen focus-forming virus was used to produce erythroleukemias. Uninfected interleukin-3-dependent basophil-mast cell progenitors coproliferated amidst the spleen focus-forming virus-infected leukemic cells. Splenic proliferation of normal stem cells is apparently a host response to leukemogenesis, and we propose that it may contribute to certain retroviral diseases.

Original languageEnglish (US)
Pages (from-to)4434-4437
Number of pages4
JournalJournal of Virology
Volume63
Issue number10
StatePublished - 1989

Fingerprint

Spleen Focus-Forming Viruses
interleukin-3
Leukemia, Erythroblastic, Acute
Interleukin-3
spleen
viruses
Basophils
Hematopoietic Stem Cells
Mast Cells
Leukemia
basophils
Stem Cells
Spleen
cells
mast cells
Viruses
leukemia
stem cells
mice

ASJC Scopus subject areas

  • Immunology

Cite this

Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia. / Spiro, C.; Gliniak, B. C.; Kabat, David.

In: Journal of Virology, Vol. 63, No. 10, 1989, p. 4434-4437.

Research output: Contribution to journalArticle

Spiro, C, Gliniak, BC & Kabat, D 1989, 'Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia', Journal of Virology, vol. 63, no. 10, pp. 4434-4437.
Spiro, C. ; Gliniak, B. C. ; Kabat, David. / Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia. In: Journal of Virology. 1989 ; Vol. 63, No. 10. pp. 4434-4437.
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