TY - JOUR
T1 - Splanchnic neural regulation of pancreatic polypeptide release in the isolated perfused human pancreas
AU - Brunicardi, F. Charles
AU - Druck, Paul
AU - Seymour, Neal E.
AU - Sun, You Su
AU - Gingerich, Ronald L.
AU - Elahi, Dariush
AU - Andersen, Dana K.
N1 - Funding Information:
From The Departments of Surgery and Medicine, State University of New York-Health Science Center, Brooklyn, New York; the Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri; and the Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston. Massachusetts. Suuoorted in Dart bv the Foundation for Surgical Education and Investigation, Inc., Brooklyn, New York, and by the National Institutes of Health, Bethesda, Maryland (Grant AM-30336).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/1
Y1 - 1989/1
N2 - The isolated perfused human pancreas was employed as a model in which electrical stimulation of the celiac mixed neural bundle was performed in the presence and absence of selective neural antagonists. Stimulation of the celiac neural bundle in the presence of hyperglycemia resulted in augmentation of pancreatic polypeptide release. Cholinergic stimulation appears to predominate, whereas beta-adrenergic fibers stimulate pancreatic polypeptide-cell secretion, and alpha-adrenergic fibers inhibit pancreatic polypeptide release. During euglycemia, both cholinergic stimulation and gastric inhibitory polypeptide infusion resulted in a marked release of pancreatic polypeptide. These stimulatory effects were additive, which suggests a linked hormonal and neural mechanism of pancreatic polypeptide release after a meal. In this in vitro human model, our data confirm that the splanchnic innervation of the pancreas has a potent regulatory role in pancreatic hormone release in man.
AB - The isolated perfused human pancreas was employed as a model in which electrical stimulation of the celiac mixed neural bundle was performed in the presence and absence of selective neural antagonists. Stimulation of the celiac neural bundle in the presence of hyperglycemia resulted in augmentation of pancreatic polypeptide release. Cholinergic stimulation appears to predominate, whereas beta-adrenergic fibers stimulate pancreatic polypeptide-cell secretion, and alpha-adrenergic fibers inhibit pancreatic polypeptide release. During euglycemia, both cholinergic stimulation and gastric inhibitory polypeptide infusion resulted in a marked release of pancreatic polypeptide. These stimulatory effects were additive, which suggests a linked hormonal and neural mechanism of pancreatic polypeptide release after a meal. In this in vitro human model, our data confirm that the splanchnic innervation of the pancreas has a potent regulatory role in pancreatic hormone release in man.
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U2 - 10.1016/0002-9610(89)90419-4
DO - 10.1016/0002-9610(89)90419-4
M3 - Article
C2 - 2910127
AN - SCOPUS:0024538037
VL - 157
SP - 50
EP - 57
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 1
ER -