Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence

R. J. Santen, H. E. Kulin, Donald (Lynn) Loriaux, J. Friend

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Spironolactone (Aldactone1) acts as an antiandrogen by blocking testosterone synthesis and competing with testosterone for the androgen receptor. These properties of the mineralocorticoid antagonist were used in an attempt to interrupt the gonadal pituitary hypothalamic negative feedback axis and thereby stimulate LH and FSH in 7 boys with delayed puberty. Following administration of aldactone (5 mg/kg) daily for one week, there was a significant (P

Original languageEnglish (US)
Pages (from-to)1386-1390
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number6
StatePublished - 1976
Externally publishedYes

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Spironolactone
Androgen Receptors
Gonadotropins
Testosterone
Delayed Puberty
Mineralocorticoid Receptor Antagonists
Androgen Antagonists
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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence. / Santen, R. J.; Kulin, H. E.; Loriaux, Donald (Lynn); Friend, J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 43, No. 6, 1976, p. 1386-1390.

Research output: Contribution to journalArticle

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