Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence

R. J. Santen, H. E. Kulin, Donald (Lynn) Loriaux, J. Friend

Research output: Contribution to journalArticle

17 Scopus citations


Spironolactone (Aldactone1) acts as an antiandrogen by blocking testosterone synthesis and competing with testosterone for the androgen receptor. These properties of the mineralocorticoid antagonist were used in an attempt to interrupt the gonadal pituitary hypothalamic negative feedback axis and thereby stimulate LH and FSH in 7 boys with delayed puberty. Following administration of aldactone (5 mg/kg) daily for one week, there was a significant (P

Original languageEnglish (US)
Pages (from-to)1386-1390
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
Publication statusPublished - 1976
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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