Abstract
Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII). All four SCLs were strongly CD34 positive (95 to 100% of cells) and focally factor XIIIa positive (average 16% of cells). Tumor cells were S-100, actin and factor VIII negative. Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 546-550 |
| Number of pages | 5 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
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Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study. / Templeton, Stephen F.; Solomon, Alvin Jr.
In: Journal of Cutaneous Pathology, Vol. 23, No. 6, 1996, p. 546-550.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study
AU - Templeton, Stephen F.
AU - Solomon, Alvin Jr
PY - 1996
Y1 - 1996
N2 - Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII). All four SCLs were strongly CD34 positive (95 to 100% of cells) and focally factor XIIIa positive (average 16% of cells). Tumor cells were S-100, actin and factor VIII negative. Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria.
AB - Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII). All four SCLs were strongly CD34 positive (95 to 100% of cells) and focally factor XIIIa positive (average 16% of cells). Tumor cells were S-100, actin and factor VIII negative. Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria.
UR - http://www.scopus.com/inward/record.url?scp=0030463699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030463699&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0560.1996.tb01447.x
DO - 10.1111/j.1600-0560.1996.tb01447.x
M3 - Article
C2 - 9001985
AN - SCOPUS:0030463699
VL - 23
SP - 546
EP - 550
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 6
ER -