Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study

Stephen F. Templeton, Alvin Jr Solomon

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII). All four SCLs were strongly CD34 positive (95 to 100% of cells) and focally factor XIIIa positive (average 16% of cells). Tumor cells were S-100, actin and factor VIII negative. Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria.

Original languageEnglish (US)
Pages (from-to)546-550
Number of pages5
JournalJournal of Cutaneous Pathology
Volume23
Issue number6
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Lipoma
Factor XIIIa
Factor VIII
Actins
Angiolipoma
Soft Tissue Neoplasms
Dermatofibrosarcoma
Neurofibroma
Neurilemmoma
Neoplasms
Differential Diagnosis
Antibodies

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study. / Templeton, Stephen F.; Solomon, Alvin Jr.

In: Journal of Cutaneous Pathology, Vol. 23, No. 6, 1996, p. 546-550.

Research output: Contribution to journalArticle

Templeton, Stephen F. ; Solomon, Alvin Jr. / Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study. In: Journal of Cutaneous Pathology. 1996 ; Vol. 23, No. 6. pp. 546-550.
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