Spermatogonial stem cell transplantation to the testis

Shaun Goodyear, Ralph Brinster

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Spermatogonial stem cells (SSCs) are located in the basal region of the seminiferous tubules and provide a self-renewing reservoir from which progenitor spermatogonia arise and transiently amplify in number before transition to a differentiating state. SSC transplantation involves grafting mouse testicular cells into the seminiferous tubules of an aspermic recipient testis that is generated either by chemical (e.g., busulfan) treatment or genetic mutations.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalCold Spring Harbor Protocols
Volume2017
Issue number4
DOIs
StatePublished - Apr 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Spermatogonial stem cell transplantation to the testis'. Together they form a unique fingerprint.

Cite this