Spectroscopic imaging of the uptake kinetics of human brain ethanol

Hoby P. Hetherington; F. Telang; J. W. Pan; M. Sammi; D. Schuhlein; P. Molina; N. D. Volkow

doi:10.1002/(SICI)1522-2594(199912)42:6<1019::AID-MRM5>3.0.CO;2-Y

Spectroscopic imaging of the uptake kinetics of human brain ethanol

Hoby P. Hetherington, F. Telang, J. W. Pan, M. Sammi, D. Schuhlein, P. Molina, N. D. Volkow

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Previous measurements of the ratio of brain to venous blood alcohol have ranged from 21-100%, depending on the experimental model, pulse sequence, and the concentration reference used. The goal of this study was to evaluate the uptake kinetics and visibility of brain ethanol in comparison to venous blood levels using a pulse sequence that minimizes uncertainties due to differences in J-modulation, T₁, and T₂ between ethanol and the concentration standard. This was achieved using a short TE (24 msec) spin echo sequence with a semiselective refocusing pulse to minimize J-modulation losses of the ethanol. Brain ethanol levels were measured with 10-min time resolution using a 16 x 16 spectroscopic imaging matrix with nominal voxels of 1.44 cc. During the course of the study, the brain/blood alcohol ratio declined from a value of 1.54 ± 0.74 at 35 min after drinking to a final value of 0.93 ± 0.16 at 85 min postdrinking.

Original language	English (US)
Pages (from-to)	1019-1026
Number of pages	8
Journal	Magnetic Resonance in Medicine
Volume	42
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1522-2594(199912)42:6<1019::AID-MRM5>3.0.CO;2-Y
State	Published - 1999
Externally published	Yes

Keywords

Alcohol
Blood
Brain
NMR spectroscopy
Visibility

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/(SICI)1522-2594(199912)42:6<1019::AID-MRM5>3.0.CO;2-Y

Cite this

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title = "Spectroscopic imaging of the uptake kinetics of human brain ethanol",

abstract = "Previous measurements of the ratio of brain to venous blood alcohol have ranged from 21-100%, depending on the experimental model, pulse sequence, and the concentration reference used. The goal of this study was to evaluate the uptake kinetics and visibility of brain ethanol in comparison to venous blood levels using a pulse sequence that minimizes uncertainties due to differences in J-modulation, T1, and T2 between ethanol and the concentration standard. This was achieved using a short TE (24 msec) spin echo sequence with a semiselective refocusing pulse to minimize J-modulation losses of the ethanol. Brain ethanol levels were measured with 10-min time resolution using a 16 x 16 spectroscopic imaging matrix with nominal voxels of 1.44 cc. During the course of the study, the brain/blood alcohol ratio declined from a value of 1.54 ± 0.74 at 35 min after drinking to a final value of 0.93 ± 0.16 at 85 min postdrinking.",

keywords = "Alcohol, Blood, Brain, NMR spectroscopy, Visibility",

author = "Hetherington, {Hoby P.} and F. Telang and Pan, {J. W.} and M. Sammi and D. Schuhlein and P. Molina and Volkow, {N. D.}",

year = "1999",

doi = "10.1002/(SICI)1522-2594(199912)42:6<1019::AID-MRM5>3.0.CO;2-Y",

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AU - Hetherington, Hoby P.

AU - Telang, F.

AU - Pan, J. W.

AU - Sammi, M.

AU - Schuhlein, D.

AU - Molina, P.

AU - Volkow, N. D.

PY - 1999

Y1 - 1999

N2 - Previous measurements of the ratio of brain to venous blood alcohol have ranged from 21-100%, depending on the experimental model, pulse sequence, and the concentration reference used. The goal of this study was to evaluate the uptake kinetics and visibility of brain ethanol in comparison to venous blood levels using a pulse sequence that minimizes uncertainties due to differences in J-modulation, T1, and T2 between ethanol and the concentration standard. This was achieved using a short TE (24 msec) spin echo sequence with a semiselective refocusing pulse to minimize J-modulation losses of the ethanol. Brain ethanol levels were measured with 10-min time resolution using a 16 x 16 spectroscopic imaging matrix with nominal voxels of 1.44 cc. During the course of the study, the brain/blood alcohol ratio declined from a value of 1.54 ± 0.74 at 35 min after drinking to a final value of 0.93 ± 0.16 at 85 min postdrinking.

AB - Previous measurements of the ratio of brain to venous blood alcohol have ranged from 21-100%, depending on the experimental model, pulse sequence, and the concentration reference used. The goal of this study was to evaluate the uptake kinetics and visibility of brain ethanol in comparison to venous blood levels using a pulse sequence that minimizes uncertainties due to differences in J-modulation, T1, and T2 between ethanol and the concentration standard. This was achieved using a short TE (24 msec) spin echo sequence with a semiselective refocusing pulse to minimize J-modulation losses of the ethanol. Brain ethanol levels were measured with 10-min time resolution using a 16 x 16 spectroscopic imaging matrix with nominal voxels of 1.44 cc. During the course of the study, the brain/blood alcohol ratio declined from a value of 1.54 ± 0.74 at 35 min after drinking to a final value of 0.93 ± 0.16 at 85 min postdrinking.

KW - Alcohol

KW - Blood

KW - Brain

KW - NMR spectroscopy

KW - Visibility

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ER -

Spectroscopic imaging of the uptake kinetics of human brain ethanol

Abstract

Keywords

ASJC Scopus subject areas

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