Spectroscopic imaging of the uptake kinetics of human brain ethanol

Hoby P. Hetherington, F. Telang, J. W. Pan, Manoj Sammi, D. Schuhlein, P. Molina, N. D. Volkow

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Previous measurements of the ratio of brain to venous blood alcohol have ranged from 21-100%, depending on the experimental model, pulse sequence, and the concentration reference used. The goal of this study was to evaluate the uptake kinetics and visibility of brain ethanol in comparison to venous blood levels using a pulse sequence that minimizes uncertainties due to differences in J-modulation, T1, and T2 between ethanol and the concentration standard. This was achieved using a short TE (24 msec) spin echo sequence with a semiselective refocusing pulse to minimize J-modulation losses of the ethanol. Brain ethanol levels were measured with 10-min time resolution using a 16 x 16 spectroscopic imaging matrix with nominal voxels of 1.44 cc. During the course of the study, the brain/blood alcohol ratio declined from a value of 1.54 ± 0.74 at 35 min after drinking to a final value of 0.93 ± 0.16 at 85 min postdrinking.

Original languageEnglish (US)
Pages (from-to)1019-1026
Number of pages8
JournalMagnetic Resonance in Medicine
Volume42
Issue number6
DOIs
Publication statusPublished - 1999
Externally publishedYes

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Keywords

  • Alcohol
  • Blood
  • Brain
  • NMR spectroscopy
  • Visibility

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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