Spectral domain optical coherence tomographic imaging of geographic atrophy

Brandon Lujan, Philip J. Rosenfeld, Giovanni Gregori, Fenghua Wang, Robert W. Knighton, William J. Feuer, Carmen A. Puliafito

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

■ BACKGROUND AND OBJECTIVE: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). ■ PATIENTs AND METHODs: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. ■ RESULTS: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. ■ CONCLUSION: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging
Volume40
Issue number2
DOIs
StatePublished - Mar 2009
Externally publishedYes

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Geographic Atrophy
Optical Coherence Tomography
Choroid
Retinal Pigment Epithelium

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Lujan, B., Rosenfeld, P. J., Gregori, G., Wang, F., Knighton, R. W., Feuer, W. J., & Puliafito, C. A. (2009). Spectral domain optical coherence tomographic imaging of geographic atrophy. Ophthalmic Surgery Lasers and Imaging, 40(2), 96-101. https://doi.org/10.3928/15428877-20090301-16

Spectral domain optical coherence tomographic imaging of geographic atrophy. / Lujan, Brandon; Rosenfeld, Philip J.; Gregori, Giovanni; Wang, Fenghua; Knighton, Robert W.; Feuer, William J.; Puliafito, Carmen A.

In: Ophthalmic Surgery Lasers and Imaging, Vol. 40, No. 2, 03.2009, p. 96-101.

Research output: Contribution to journalArticle

Lujan, B, Rosenfeld, PJ, Gregori, G, Wang, F, Knighton, RW, Feuer, WJ & Puliafito, CA 2009, 'Spectral domain optical coherence tomographic imaging of geographic atrophy', Ophthalmic Surgery Lasers and Imaging, vol. 40, no. 2, pp. 96-101. https://doi.org/10.3928/15428877-20090301-16
Lujan, Brandon ; Rosenfeld, Philip J. ; Gregori, Giovanni ; Wang, Fenghua ; Knighton, Robert W. ; Feuer, William J. ; Puliafito, Carmen A. / Spectral domain optical coherence tomographic imaging of geographic atrophy. In: Ophthalmic Surgery Lasers and Imaging. 2009 ; Vol. 40, No. 2. pp. 96-101.
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