Spectral domain optical coherence tomographic imaging of geographic atrophy

Brandon J. Lujan, Philip J. Rosenfeld, Giovanni Gregori, Fenghua Wang, Robert W. Knighton, William J. Feuer, Carmen A. Puliafito

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

■ BACKGROUND AND OBJECTIVE: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). ■ PATIENTs AND METHODs: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. ■ RESULTS: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. ■ CONCLUSION: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging
Volume40
Issue number2
DOIs
StatePublished - Mar 1 2009

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ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Lujan, B. J., Rosenfeld, P. J., Gregori, G., Wang, F., Knighton, R. W., Feuer, W. J., & Puliafito, C. A. (2009). Spectral domain optical coherence tomographic imaging of geographic atrophy. Ophthalmic Surgery Lasers and Imaging, 40(2), 96-101. https://doi.org/10.3928/15428877-20090301-16