Abstract
Although the phenotypic and regulatory properties of the CD4 +CD25+ T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4+CD25+ Treg population includes the recognition of a broad spectrum of human TCR CDR2 determinants found in the germline V gene repertoire as well as that of a clonotypic nongermline-encoded CDR3β sequence present in a recombinant soluble T cell receptor (TCR) protein. Regulatory activity was demonstrated in T cell lines responsive to TCR but not in T cell lines responsive to control antigens. Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants.
Original language | English (US) |
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Pages (from-to) | 129-140 |
Number of pages | 12 |
Journal | Journal of Neuroscience Research |
Volume | 76 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1 2004 |
Keywords
- Autoimmunity
- Multiple sclerosis
- Regulatory T cells
- Suppression
- T cell receptor
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience