TY - JOUR
T1 - Specification of retinogeniculate X and Y axon arbors in cats
T2 - Fundamental differences in developmental programs
AU - Garraghty, P. E.
AU - Roe, A.
AU - Sur, M.
PY - 1998/5/15
Y1 - 1998/5/15
N2 - Monocular enucleation at E36, followed by intracellular labeling of single, physiologically identified X and Y axons, demonstrates fundamental differences in their termination patterns within the lateral geniculate nucleus (LGN). X axons have arbors that appear normal in their dorsoventral extent, though some are located in inappropriate regions of the LGN. Y axons have arbors that are either abnormally tall, spanning the entire extent of the LGN, or of normal height but located in inappropriate regions of the LGN. These termination patterns resemble patterns seen after monocular enucleation at E44, and reinforce the conclusion that X and Y axons differ fundamentally in the cues that constrain the dorsoventral extents of their arbors.
AB - Monocular enucleation at E36, followed by intracellular labeling of single, physiologically identified X and Y axons, demonstrates fundamental differences in their termination patterns within the lateral geniculate nucleus (LGN). X axons have arbors that appear normal in their dorsoventral extent, though some are located in inappropriate regions of the LGN. Y axons have arbors that are either abnormally tall, spanning the entire extent of the LGN, or of normal height but located in inappropriate regions of the LGN. These termination patterns resemble patterns seen after monocular enucleation at E44, and reinforce the conclusion that X and Y axons differ fundamentally in the cues that constrain the dorsoventral extents of their arbors.
KW - Binocular competition
KW - Lateral geniculate nucleus
KW - Retinogeniculate development
UR - http://www.scopus.com/inward/record.url?scp=0032524405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032524405&partnerID=8YFLogxK
U2 - 10.1016/S0165-3806(97)00223-X
DO - 10.1016/S0165-3806(97)00223-X
M3 - Article
C2 - 9593907
AN - SCOPUS:0032524405
VL - 107
SP - 227
EP - 231
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 2
ER -