Specification of retinogeniculate X and Y axon arbors in cats: Fundamental differences in developmental programs

P. E. Garraghty, A. Roe, M. Sur

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Monocular enucleation at E36, followed by intracellular labeling of single, physiologically identified X and Y axons, demonstrates fundamental differences in their termination patterns within the lateral geniculate nucleus (LGN). X axons have arbors that appear normal in their dorsoventral extent, though some are located in inappropriate regions of the LGN. Y axons have arbors that are either abnormally tall, spanning the entire extent of the LGN, or of normal height but located in inappropriate regions of the LGN. These termination patterns resemble patterns seen after monocular enucleation at E44, and reinforce the conclusion that X and Y axons differ fundamentally in the cues that constrain the dorsoventral extents of their arbors.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalDevelopmental Brain Research
Volume107
Issue number2
DOIs
StatePublished - May 15 1998

Keywords

  • Binocular competition
  • Lateral geniculate nucleus
  • Retinogeniculate development

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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