@article{602a99f4068f47d28c252510b0db8ab2,
title = "Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents",
abstract = "Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic RNAse causes potent and specific killing of the lymphoma cells in vitro. This translates to anti-tumor effects in human lymphoma models in SCID mice. RNA damage caused by RNAses could be an important alternative to standard DNA damaging chemotherapeutics. Moreover, targeted RNAses may overcome problems of toxicity and immunogenicity associated with plant or bacterial toxin containing immunotoxins.",
keywords = "Antibody, Apoptosis, Cancer, Immunotoxin, Ribonuclease",
author = "Newton, {Dianne L.} and Hansen, {Hans J.} and Huaitian Liu and Dale Ruby and Iordanov, {Mihail S.} and Magun, {Bruce E.} and Goldenberg, {David M.} and Rybak, {Susanna M.}",
note = "Funding Information: We thank Stanley Mikulski for his suggestions and Alfacell Corporation for supplying onconase. We very much appreciate the help of Miriam Hursey and Lisa Grey. We are most grateful for the interest and support of Dr Edward A. Sausville. This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. NO1-CO-56000; by US PHS Grants CA-39360 and ES-08456 to B.E.M. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The publisher or recipient acknowledges right of the US Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article. ",
year = "2001",
doi = "10.1016/S1040-8428(01)00116-0",
language = "English (US)",
volume = "39",
pages = "79--86",
journal = "Critical Reviews in Oncology/Hematology",
issn = "1040-8428",
publisher = "Elsevier Ireland Ltd",
number = "1-2",
}