Specific target-directed axonal outgrowth from transplanted embryonic rodent retinae into neonatal rat superior colliculus

Mark H. Hankin, Raymond D. Lund

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

We have investigated whether there is evidence of target-directed growth of retinal axons to the tectum, and whether the surface of the rostral brainstem is an obligatory substrate for growing optic axons by transplanting embryonic mouse retinae to the cerebral aqueduct of neonatal rats. Such retinae emit axons that grow dorsally through the brain parenchyma to reach the superficial layers of the superior colliculus either by running dorsally along the midline, or by following a dorsally directed, radially arching course through the brain parenchyma. Studies of the early outgrowth pattern from transplanted retinae, and comparison studies of the axonal outgrowth from similarly placed cortical grafts suggest that outgrowth of retinal axons is target-directed and specific to optic axons.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalBrain research
Volume408
Issue number1-2
DOIs
StatePublished - Apr 7 1987

Keywords

  • Allograft
  • Axon guidance
  • Cortex
  • Retina
  • Superior colliculus
  • Xenograft

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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