Specific splice variants are associated with Parkinson's disease

Jose A. Santiago, Clemens R. Scherzer, Judith A. Potashkin, Bradley T. Hyman, Adrian J. Ivinson, Ana Trisini-Lipsanopoulos, Kaltra Dhima, Stephen Bayer, Kaitlin C. Lockhart, Thomas Yi, Zhixiang Liao, Ashley N. Hoesing, Karen Duong, Sarah Roderick, Lewis R. Sudarsky, Michael T. Hayes, Reisa Sperling, John H. Growdon, Michael A. Schwarzschild, Albert Y. HungAlice W. Flaherty, Deborah Blacker, Anne Marie Wills, U. Shivraj Sohur, Vivek Unni, Nicte I. Mejia, Anand Viswanathan, Stephen N. Gomperts, Vikram Khurana, Mark W. Albers, Rebecca K. Rudel, Joseph J. Locascio, Dennis J. Selkoe, Michael G. Schlossmacher, Alberto Ascherio

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study. Methods: Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study. Results: Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD. Conclusions: These results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.

Original languageEnglish (US)
Pages (from-to)1724-1727
Number of pages4
JournalMovement Disorders
Volume28
Issue number12
DOIs
StatePublished - Oct 2013
Externally publishedYes

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Parkinson Disease
Biomarkers
Symptom Assessment
Population Control

Keywords

  • Biomarker
  • Gene expression
  • Neurodegeneration
  • Parkinson's disease
  • Splicing

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Santiago, J. A., Scherzer, C. R., Potashkin, J. A., Hyman, B. T., Ivinson, A. J., Trisini-Lipsanopoulos, A., ... Ascherio, A. (2013). Specific splice variants are associated with Parkinson's disease. Movement Disorders, 28(12), 1724-1727. https://doi.org/10.1002/mds.25635

Specific splice variants are associated with Parkinson's disease. / Santiago, Jose A.; Scherzer, Clemens R.; Potashkin, Judith A.; Hyman, Bradley T.; Ivinson, Adrian J.; Trisini-Lipsanopoulos, Ana; Dhima, Kaltra; Bayer, Stephen; Lockhart, Kaitlin C.; Yi, Thomas; Liao, Zhixiang; Hoesing, Ashley N.; Duong, Karen; Roderick, Sarah; Sudarsky, Lewis R.; Hayes, Michael T.; Sperling, Reisa; Growdon, John H.; Schwarzschild, Michael A.; Hung, Albert Y.; Flaherty, Alice W.; Blacker, Deborah; Wills, Anne Marie; Sohur, U. Shivraj; Unni, Vivek; Mejia, Nicte I.; Viswanathan, Anand; Gomperts, Stephen N.; Khurana, Vikram; Albers, Mark W.; Rudel, Rebecca K.; Locascio, Joseph J.; Selkoe, Dennis J.; Schlossmacher, Michael G.; Ascherio, Alberto.

In: Movement Disorders, Vol. 28, No. 12, 10.2013, p. 1724-1727.

Research output: Contribution to journalArticle

Santiago, JA, Scherzer, CR, Potashkin, JA, Hyman, BT, Ivinson, AJ, Trisini-Lipsanopoulos, A, Dhima, K, Bayer, S, Lockhart, KC, Yi, T, Liao, Z, Hoesing, AN, Duong, K, Roderick, S, Sudarsky, LR, Hayes, MT, Sperling, R, Growdon, JH, Schwarzschild, MA, Hung, AY, Flaherty, AW, Blacker, D, Wills, AM, Sohur, US, Unni, V, Mejia, NI, Viswanathan, A, Gomperts, SN, Khurana, V, Albers, MW, Rudel, RK, Locascio, JJ, Selkoe, DJ, Schlossmacher, MG & Ascherio, A 2013, 'Specific splice variants are associated with Parkinson's disease', Movement Disorders, vol. 28, no. 12, pp. 1724-1727. https://doi.org/10.1002/mds.25635
Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A et al. Specific splice variants are associated with Parkinson's disease. Movement Disorders. 2013 Oct;28(12):1724-1727. https://doi.org/10.1002/mds.25635
Santiago, Jose A. ; Scherzer, Clemens R. ; Potashkin, Judith A. ; Hyman, Bradley T. ; Ivinson, Adrian J. ; Trisini-Lipsanopoulos, Ana ; Dhima, Kaltra ; Bayer, Stephen ; Lockhart, Kaitlin C. ; Yi, Thomas ; Liao, Zhixiang ; Hoesing, Ashley N. ; Duong, Karen ; Roderick, Sarah ; Sudarsky, Lewis R. ; Hayes, Michael T. ; Sperling, Reisa ; Growdon, John H. ; Schwarzschild, Michael A. ; Hung, Albert Y. ; Flaherty, Alice W. ; Blacker, Deborah ; Wills, Anne Marie ; Sohur, U. Shivraj ; Unni, Vivek ; Mejia, Nicte I. ; Viswanathan, Anand ; Gomperts, Stephen N. ; Khurana, Vikram ; Albers, Mark W. ; Rudel, Rebecca K. ; Locascio, Joseph J. ; Selkoe, Dennis J. ; Schlossmacher, Michael G. ; Ascherio, Alberto. / Specific splice variants are associated with Parkinson's disease. In: Movement Disorders. 2013 ; Vol. 28, No. 12. pp. 1724-1727.
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AU - Santiago, Jose A.

AU - Scherzer, Clemens R.

AU - Potashkin, Judith A.

AU - Hyman, Bradley T.

AU - Ivinson, Adrian J.

AU - Trisini-Lipsanopoulos, Ana

AU - Dhima, Kaltra

AU - Bayer, Stephen

AU - Lockhart, Kaitlin C.

AU - Yi, Thomas

AU - Liao, Zhixiang

AU - Hoesing, Ashley N.

AU - Duong, Karen

AU - Roderick, Sarah

AU - Sudarsky, Lewis R.

AU - Hayes, Michael T.

AU - Sperling, Reisa

AU - Growdon, John H.

AU - Schwarzschild, Michael A.

AU - Hung, Albert Y.

AU - Flaherty, Alice W.

AU - Blacker, Deborah

AU - Wills, Anne Marie

AU - Sohur, U. Shivraj

AU - Unni, Vivek

AU - Mejia, Nicte I.

AU - Viswanathan, Anand

AU - Gomperts, Stephen N.

AU - Khurana, Vikram

AU - Albers, Mark W.

AU - Rudel, Rebecca K.

AU - Locascio, Joseph J.

AU - Selkoe, Dennis J.

AU - Schlossmacher, Michael G.

AU - Ascherio, Alberto

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N2 - Background: Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study. Methods: Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study. Results: Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD. Conclusions: These results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.

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