Specific pathogen free macaque colonies: A review of principles and recent advances for viral testing and colony management

Joann L. Yee, Thomas H. Vanderford, Elizabeth S. Didier, Stanton Gray, Anne Lewis, Jeffrey Roberts, Kerry Taylor, Rudolf P. Bohm

    Research output: Contribution to journalReview articlepeer-review

    12 Scopus citations

    Abstract

    Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.

    Original languageEnglish (US)
    Pages (from-to)55-78
    Number of pages24
    JournalJournal of medical primatology
    Volume45
    Issue number2
    DOIs
    StatePublished - Apr 1 2016

    Keywords

    • Herpes B virus
    • Macaque colony management
    • Simian T-cell lymphotropic virus
    • Simian betaretrovirus
    • Simian immunodeficiency virus
    • Specific pathogen free
    • Virus testing

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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