Specific pathogen free macaque colonies: A review of principles and recent advances for viral testing and colony management

Joann L. Yee, Thomas H. Vanderford, Elizabeth S. Didier, Stanton Gray, Anne Lewis, Jeffrey Roberts, Kerry Taylor, Rudolf P. Bohm

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.

    Original languageEnglish (US)
    Pages (from-to)55-78
    Number of pages24
    JournalJournal of Medical Primatology
    Volume45
    Issue number2
    DOIs
    StatePublished - Apr 1 2016

    Fingerprint

    Specific Pathogen-Free Organisms
    Macaca
    pathogens
    infrastructure
    Research
    testing
    Animal Husbandry
    National Institutes of Health
    Biological Sciences
    biomedical research
    animal husbandry
    National Institutes of Health (U.S.)
    Contracts
    Biomedical Research
    decision making
    Decision Making
    physiology
    Animal Models
    animal models
    Maintenance

    Keywords

    • Herpes B virus
    • Macaque colony management
    • Simian betaretrovirus
    • Simian immunodeficiency virus
    • Simian T-cell lymphotropic virus
    • Specific pathogen free
    • Virus testing

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

    Cite this

    Specific pathogen free macaque colonies : A review of principles and recent advances for viral testing and colony management. / Yee, Joann L.; Vanderford, Thomas H.; Didier, Elizabeth S.; Gray, Stanton; Lewis, Anne; Roberts, Jeffrey; Taylor, Kerry; Bohm, Rudolf P.

    In: Journal of Medical Primatology, Vol. 45, No. 2, 01.04.2016, p. 55-78.

    Research output: Contribution to journalArticle

    Yee, Joann L. ; Vanderford, Thomas H. ; Didier, Elizabeth S. ; Gray, Stanton ; Lewis, Anne ; Roberts, Jeffrey ; Taylor, Kerry ; Bohm, Rudolf P. / Specific pathogen free macaque colonies : A review of principles and recent advances for viral testing and colony management. In: Journal of Medical Primatology. 2016 ; Vol. 45, No. 2. pp. 55-78.
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