Spatial memory performance associated with measures of immune function in elderly female rhesus macaques

G. E. Haley, Henryk Urbanski, Steven Kohama, I. Messaoudi, Jacob Raber

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M1) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.

Original languageEnglish (US)
Pages (from-to)117-121
Number of pages5
JournalEuropean Geriatric Medicine
Volume2
Issue number2
DOIs
StatePublished - Apr 2011

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Macaca mulatta
Vaccination
Interferons
Sleep
T-Lymphocytes
Antibodies
Adaptive Immunity
Muscarinic Receptors
Antibody Formation
Spatial Memory

Keywords

  • Circadian activity
  • Immune senescence
  • Spatial learning and memory

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology

Cite this

Spatial memory performance associated with measures of immune function in elderly female rhesus macaques. / Haley, G. E.; Urbanski, Henryk; Kohama, Steven; Messaoudi, I.; Raber, Jacob.

In: European Geriatric Medicine, Vol. 2, No. 2, 04.2011, p. 117-121.

Research output: Contribution to journalArticle

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