Spatial memory performance associated with measures of immune function in elderly female rhesus macaques

G. E. Haley; H. F. Urbanski; S. G. Kohama; I. Messaoudi; J. Raber

doi:10.1016/j.eurger.2011.01.002

Spatial memory performance associated with measures of immune function in elderly female rhesus macaques

G. E. Haley, H. F. Urbanski, S. G. Kohama, I. Messaoudi, J. Raber

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M₁) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.

Original language	English (US)
Pages (from-to)	117-121
Number of pages	5
Journal	European Geriatric Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.eurger.2011.01.002
State	Published - Apr 2011

Keywords

Circadian activity
Immune senescence
Spatial learning and memory

ASJC Scopus subject areas

Gerontology
Geriatrics and Gerontology

Access to Document

10.1016/j.eurger.2011.01.002

Cite this

@article{25ceeb36becb4ac4842c2f1a808abb25,

title = "Spatial memory performance associated with measures of immune function in elderly female rhesus macaques",

abstract = "We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M1) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.",

keywords = "Circadian activity, Immune senescence, Spatial learning and memory",

author = "Haley, {G. E.} and Urbanski, {H. F.} and Kohama, {S. G.} and I. Messaoudi and J. Raber",

note = "Funding Information: This work was supported by NIH Grants AG023477, AG029612, and RR-000163, as well as grants from the Medical Research Foundation, Center for Gender based Medicine (OHSU) and the Brookdale Foundation. ",

year = "2011",

month = apr,

doi = "10.1016/j.eurger.2011.01.002",

language = "English (US)",

volume = "2",

pages = "117--121",

journal = "European Geriatric Medicine",

issn = "1878-7649",

publisher = "Elsevier Masson",

number = "2",

}

TY - JOUR

T1 - Spatial memory performance associated with measures of immune function in elderly female rhesus macaques

AU - Haley, G. E.

AU - Urbanski, H. F.

AU - Kohama, S. G.

AU - Messaoudi, I.

AU - Raber, J.

N1 - Funding Information: This work was supported by NIH Grants AG023477, AG029612, and RR-000163, as well as grants from the Medical Research Foundation, Center for Gender based Medicine (OHSU) and the Brookdale Foundation.

PY - 2011/4

Y1 - 2011/4

N2 - We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M1) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.

AB - We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M1) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.

KW - Circadian activity

KW - Immune senescence

KW - Spatial learning and memory

UR - http://www.scopus.com/inward/record.url?scp=79953295939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953295939&partnerID=8YFLogxK

U2 - 10.1016/j.eurger.2011.01.002

DO - 10.1016/j.eurger.2011.01.002

M3 - Article

AN - SCOPUS:79953295939

SN - 1878-7649

VL - 2

SP - 117

EP - 121

JO - European Geriatric Medicine

JF - European Geriatric Medicine

IS - 2

ER -

Spatial memory performance associated with measures of immune function in elderly female rhesus macaques

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this