Spatial and temporal variations of cortical growth during gyrogenesis in the developing ferret brain

Andrew K. Knutsen, Christopher (Chris) Kroenke, Yulin V. Chang, Larry A. Taber, Philip V. Bayly

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Spatial and temporal variations in cortical growth were studied in the neonatal ferret to illuminate the mechanisms of folding of the cerebral cortex. Cortical surface representations were created from magnetic resonance images acquired between postnatal day 4 and 35. Global measures of shape (e.g., surface area, normalized curvature, and sulcal depth) were calculated. In 2 ferrets, relative cortical growth was calculated between surfaces created from in vivo images acquired at P14, P21, and P28. The isocortical surface area transitions from a slower (12.7 mm2/day per hemisphere) to a higher rate of growth (36.7 mm2/day per hemisphere) approximately 13 days after birth, which coincides with the time of transition from neuronal proliferation to cellular morphological differentiation. Relative cortical growth increases as a function of relative geodesic distance from the origin of the transverse neurogenetic gradient and is related to the change in fractional diffusion anisotropy over the same time period. The methods presented here can be applied to study cortical growth during development in other animal models or human infants. Our results provide a quantitative spatial and temporal description of folding in cerebral cortex of the developing ferret brain, which will be important to understand the underlying mechanisms that drive folding.

Original languageEnglish (US)
Pages (from-to)488-498
Number of pages11
JournalCerebral Cortex
Volume23
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Ferrets
Brain
Growth
Cerebral Cortex
Anisotropy
Growth and Development
Magnetic Resonance Spectroscopy
Animal Models
Cell Proliferation
Parturition

Keywords

  • curvature
  • fractional anisotropy
  • intrasubject registration
  • MRI

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Spatial and temporal variations of cortical growth during gyrogenesis in the developing ferret brain. / Knutsen, Andrew K.; Kroenke, Christopher (Chris); Chang, Yulin V.; Taber, Larry A.; Bayly, Philip V.

In: Cerebral Cortex, Vol. 23, No. 2, 02.2013, p. 488-498.

Research output: Contribution to journalArticle

Knutsen, Andrew K. ; Kroenke, Christopher (Chris) ; Chang, Yulin V. ; Taber, Larry A. ; Bayly, Philip V. / Spatial and temporal variations of cortical growth during gyrogenesis in the developing ferret brain. In: Cerebral Cortex. 2013 ; Vol. 23, No. 2. pp. 488-498.
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