Somatomedins in Pregnancy: A Cross-Sectional Study of Insulin-Like Growth Factors I and II and Somatomedin Peptide Content in Normal Human Pregnancies

Darrel M. Wilson, Ann Bennett, G. Adamson David, Raymond J. Nagashima, Frances Liu, Mary L. Denatale, Raymond L. Hintz, Ron G. Rosenfeld

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

To explore the role of the somatomedins (SM) during human pregnancy, we have measured plasma levels of insulin-like growth factor I (IGF-I), IGF-II, and SM peptide content (SMPC) in 79 women in various stages of normal pregnancies. IGF-I and IGF-II were measured by specific RIAs, and SMPC was measured by a radioreceptor assay using human placental membranes. IGF-I and SMPC rose during pregnancy, showing a significant positive correlation with the length of gestation. Plasma levels of IGF-I in the third trimester averaged 324 ng/ml, a 33% increase over the first trimester average of 243 ng/ml (P < 0.05). Although IGF-II did not correlate with the length of gestation, the third trimester average was significantly higher than the first trimester average (780 vs. 630 ng/ml; P < 0.05). After delivery, both IGF-I and IGF-II levels rapidly dropped to levels significantly below those seen in the third trimester. The gestational rise in SMPC and plasma levels of both IGFI and IGF-II supports the hypothesis that SM play a role in the regulation of fetal growth.

Original languageEnglish (US)
Pages (from-to)858-861
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number5
DOIs
StatePublished - Nov 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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