Somatomedins in pregnancy: A cross-sectional study of insulin-like growth factors I and II and somatomedin peptide content in normal human pregnancies

D. M. Wilson, A. Bennett, G. D. Adamson, R. J. Nagashima, F. Liu, M. L. DeNatale, R. L. Hintz, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

To explore the role of the somatomedins (SM) during human pregnancy, we have measured plasma levels of insulin-like growth factor I (IGF-I), IGF-II, and SM peptide content (SMPC) in 79 women in various stages of normal pregnancies. IGF-I and IGF-II were measured by specific RIAs, and SMPC was measured by a radioreceptor assay using human placental membranes. IGF-I and SMPC rose during pregnancy, showing a significant positive correlation with the length of gestation. Plasma levels of IGF-I in the third trimester averaged 324 ng/ml, a 33% increase over the first trimester average of 243 ng/ml (P

Original languageEnglish (US)
Pages (from-to)858-861
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number5
StatePublished - 1982
Externally publishedYes

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Insulin-Like Growth Factor II
Somatomedins
Insulin-Like Growth Factor I
Cross-Sectional Studies
Pregnancy
Peptides
Plasmas
Radioligand Assay
Third Pregnancy Trimester
First Pregnancy Trimester
Assays
Membranes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Wilson, D. M., Bennett, A., Adamson, G. D., Nagashima, R. J., Liu, F., DeNatale, M. L., ... Rosenfeld, R. R. (1982). Somatomedins in pregnancy: A cross-sectional study of insulin-like growth factors I and II and somatomedin peptide content in normal human pregnancies. Journal of Clinical Endocrinology and Metabolism, 55(5), 858-861.

Somatomedins in pregnancy : A cross-sectional study of insulin-like growth factors I and II and somatomedin peptide content in normal human pregnancies. / Wilson, D. M.; Bennett, A.; Adamson, G. D.; Nagashima, R. J.; Liu, F.; DeNatale, M. L.; Hintz, R. L.; Rosenfeld, Ronald (Ron).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 5, 1982, p. 858-861.

Research output: Contribution to journalArticle

Wilson, DM, Bennett, A, Adamson, GD, Nagashima, RJ, Liu, F, DeNatale, ML, Hintz, RL & Rosenfeld, RR 1982, 'Somatomedins in pregnancy: A cross-sectional study of insulin-like growth factors I and II and somatomedin peptide content in normal human pregnancies', Journal of Clinical Endocrinology and Metabolism, vol. 55, no. 5, pp. 858-861.
Wilson, D. M. ; Bennett, A. ; Adamson, G. D. ; Nagashima, R. J. ; Liu, F. ; DeNatale, M. L. ; Hintz, R. L. ; Rosenfeld, Ronald (Ron). / Somatomedins in pregnancy : A cross-sectional study of insulin-like growth factors I and II and somatomedin peptide content in normal human pregnancies. In: Journal of Clinical Endocrinology and Metabolism. 1982 ; Vol. 55, No. 5. pp. 858-861.
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