TY - JOUR
T1 - Somatomedins in Pregnancy
T2 - A Cross-Sectional Study of Insulin-Like Growth Factors I and II and Somatomedin Peptide Content in Normal Human Pregnancies
AU - Wilson, Darrel M.
AU - Bennett, Ann
AU - David, G. Adamson
AU - Nagashima, Raymond J.
AU - Liu, Frances
AU - Denatale, Mary L.
AU - Hintz, Raymond L.
AU - Rosenfeld, Ron G.
PY - 1982/11
Y1 - 1982/11
N2 - To explore the role of the somatomedins (SM) during human pregnancy, we have measured plasma levels of insulin-like growth factor I (IGF-I), IGF-II, and SM peptide content (SMPC) in 79 women in various stages of normal pregnancies. IGF-I and IGF-II were measured by specific RIAs, and SMPC was measured by a radioreceptor assay using human placental membranes. IGF-I and SMPC rose during pregnancy, showing a significant positive correlation with the length of gestation. Plasma levels of IGF-I in the third trimester averaged 324 ng/ml, a 33% increase over the first trimester average of 243 ng/ml (P < 0.05). Although IGF-II did not correlate with the length of gestation, the third trimester average was significantly higher than the first trimester average (780 vs. 630 ng/ml; P < 0.05). After delivery, both IGF-I and IGF-II levels rapidly dropped to levels significantly below those seen in the third trimester. The gestational rise in SMPC and plasma levels of both IGFI and IGF-II supports the hypothesis that SM play a role in the regulation of fetal growth.
AB - To explore the role of the somatomedins (SM) during human pregnancy, we have measured plasma levels of insulin-like growth factor I (IGF-I), IGF-II, and SM peptide content (SMPC) in 79 women in various stages of normal pregnancies. IGF-I and IGF-II were measured by specific RIAs, and SMPC was measured by a radioreceptor assay using human placental membranes. IGF-I and SMPC rose during pregnancy, showing a significant positive correlation with the length of gestation. Plasma levels of IGF-I in the third trimester averaged 324 ng/ml, a 33% increase over the first trimester average of 243 ng/ml (P < 0.05). Although IGF-II did not correlate with the length of gestation, the third trimester average was significantly higher than the first trimester average (780 vs. 630 ng/ml; P < 0.05). After delivery, both IGF-I and IGF-II levels rapidly dropped to levels significantly below those seen in the third trimester. The gestational rise in SMPC and plasma levels of both IGFI and IGF-II supports the hypothesis that SM play a role in the regulation of fetal growth.
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U2 - 10.1210/jcem-55-5-858
DO - 10.1210/jcem-55-5-858
M3 - Article
C2 - 6749878
AN - SCOPUS:0020314435
SN - 0021-972X
VL - 55
SP - 858
EP - 861
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 5
ER -