Somatomedin-C in accelerated growth of children with precocious puberty

Ora Hirsch Pescovitz, Ronald (Ron) Rosenfeld, Raymond L. Hintz, Kevin Barnes, Karen Hench, Florence Comite, Donald (Lynn) Loriaux, Gordon B. Cutler

Research output: Contribution to journalArticle

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Abstract

To assess the role of somatomedin-C as a possible mediator of the growth spurt in children with central precocious puberty, we compared Sm-C levels in 40 children with central precocious puberty, 87 age-matched normal children, and 110 normal pubertal controls. Somatomedin C levels were significantly elevated for age in the children with precocious puberty (P6-Pro9-NEt-LHRH (LHRHa) for 6 months. Treatment caused a significant decrease in secondary sexual characteristics, growth rate, plasma gonadotropins, sex steroids (estradiol in the girls and testosterone in the boys), and Sm-C levels. Growth during LHRHa treatment returned to the age-appropriate rate, whereas plasma Sm-C levels, although lower than pretreatment levels, remained significantly elevated for age (Pa therapy correlate with the decreases in somatomedin C levels. Growth rates did correlate significantly, however, with plasma estradiol levels in the girls (P

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalThe Journal of Pediatrics
Volume107
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

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Precocious Puberty
Insulin-Like Growth Factor I
Growth
Estradiol
Gonadotropins
Gonadotropin-Releasing Hormone
Testosterone
Therapeutics
Steroids
Central Precocious Puberty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pescovitz, O. H., Rosenfeld, R. R., Hintz, R. L., Barnes, K., Hench, K., Comite, F., ... Cutler, G. B. (1985). Somatomedin-C in accelerated growth of children with precocious puberty. The Journal of Pediatrics, 107(1), 20-25. https://doi.org/10.1016/S0022-3476(85)80607-7

Somatomedin-C in accelerated growth of children with precocious puberty. / Pescovitz, Ora Hirsch; Rosenfeld, Ronald (Ron); Hintz, Raymond L.; Barnes, Kevin; Hench, Karen; Comite, Florence; Loriaux, Donald (Lynn); Cutler, Gordon B.

In: The Journal of Pediatrics, Vol. 107, No. 1, 1985, p. 20-25.

Research output: Contribution to journalArticle

Pescovitz, OH, Rosenfeld, RR, Hintz, RL, Barnes, K, Hench, K, Comite, F, Loriaux, DL & Cutler, GB 1985, 'Somatomedin-C in accelerated growth of children with precocious puberty', The Journal of Pediatrics, vol. 107, no. 1, pp. 20-25. https://doi.org/10.1016/S0022-3476(85)80607-7
Pescovitz OH, Rosenfeld RR, Hintz RL, Barnes K, Hench K, Comite F et al. Somatomedin-C in accelerated growth of children with precocious puberty. The Journal of Pediatrics. 1985;107(1):20-25. https://doi.org/10.1016/S0022-3476(85)80607-7
Pescovitz, Ora Hirsch ; Rosenfeld, Ronald (Ron) ; Hintz, Raymond L. ; Barnes, Kevin ; Hench, Karen ; Comite, Florence ; Loriaux, Donald (Lynn) ; Cutler, Gordon B. / Somatomedin-C in accelerated growth of children with precocious puberty. In: The Journal of Pediatrics. 1985 ; Vol. 107, No. 1. pp. 20-25.
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