Abstract
To assess the role of somatomedin-C as a possible mediator of the growth spurt in children with central precocious puberty, we compared Sm-C levels in 40 children with central precocious puberty, 87 age-matched normal children, and 110 normal pubertal controls. Somatomedin C levels were significantly elevated for age in the children with precocious puberty (P6-Pro9-NEt-LHRH (LHRHa) for 6 months. Treatment caused a significant decrease in secondary sexual characteristics, growth rate, plasma gonadotropins, sex steroids (estradiol in the girls and testosterone in the boys), and Sm-C levels. Growth during LHRHa treatment returned to the age-appropriate rate, whereas plasma Sm-C levels, although lower than pretreatment levels, remained significantly elevated for age (Pa therapy correlate with the decreases in somatomedin C levels. Growth rates did correlate significantly, however, with plasma estradiol levels in the girls (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 20-25 |
| Number of pages | 6 |
| Journal | The Journal of Pediatrics |
| Volume | 107 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Somatomedin-C in accelerated growth of children with precocious puberty. / Pescovitz, Ora Hirsch; Rosenfeld, Ronald (Ron); Hintz, Raymond L.; Barnes, Kevin; Hench, Karen; Comite, Florence; Loriaux, Donald (Lynn); Cutler, Gordon B.
In: The Journal of Pediatrics, Vol. 107, No. 1, 1985, p. 20-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Somatomedin-C in accelerated growth of children with precocious puberty
AU - Pescovitz, Ora Hirsch
AU - Rosenfeld, Ronald (Ron)
AU - Hintz, Raymond L.
AU - Barnes, Kevin
AU - Hench, Karen
AU - Comite, Florence
AU - Loriaux, Donald (Lynn)
AU - Cutler, Gordon B.
PY - 1985
Y1 - 1985
N2 - To assess the role of somatomedin-C as a possible mediator of the growth spurt in children with central precocious puberty, we compared Sm-C levels in 40 children with central precocious puberty, 87 age-matched normal children, and 110 normal pubertal controls. Somatomedin C levels were significantly elevated for age in the children with precocious puberty (P6-Pro9-NEt-LHRH (LHRHa) for 6 months. Treatment caused a significant decrease in secondary sexual characteristics, growth rate, plasma gonadotropins, sex steroids (estradiol in the girls and testosterone in the boys), and Sm-C levels. Growth during LHRHa treatment returned to the age-appropriate rate, whereas plasma Sm-C levels, although lower than pretreatment levels, remained significantly elevated for age (Pa therapy correlate with the decreases in somatomedin C levels. Growth rates did correlate significantly, however, with plasma estradiol levels in the girls (P
AB - To assess the role of somatomedin-C as a possible mediator of the growth spurt in children with central precocious puberty, we compared Sm-C levels in 40 children with central precocious puberty, 87 age-matched normal children, and 110 normal pubertal controls. Somatomedin C levels were significantly elevated for age in the children with precocious puberty (P6-Pro9-NEt-LHRH (LHRHa) for 6 months. Treatment caused a significant decrease in secondary sexual characteristics, growth rate, plasma gonadotropins, sex steroids (estradiol in the girls and testosterone in the boys), and Sm-C levels. Growth during LHRHa treatment returned to the age-appropriate rate, whereas plasma Sm-C levels, although lower than pretreatment levels, remained significantly elevated for age (Pa therapy correlate with the decreases in somatomedin C levels. Growth rates did correlate significantly, however, with plasma estradiol levels in the girls (P
UR - http://www.scopus.com/inward/record.url?scp=0021864634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021864634&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(85)80607-7
DO - 10.1016/S0022-3476(85)80607-7
M3 - Article
C2 - 3891947
AN - SCOPUS:0021864634
VL - 107
SP - 20
EP - 25
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -