Solution Dynamics and Stability of Lanthanide(III) (S)-2-(p-Nitrobenzyl)DOTA Complexes

Mark Woods, Zoltan Kovacs, Robert Kiraly, Ernö Brücher, Shanrong Zhang, A. Dean Sherry

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Addition of a benzyl substituent to the macrocyclic ring of DOTA has a substantial impact on the conformational ring flipping motion of the macrocycle in the resulting LnDOTA complexes. The p-NO2-benzyl substituent in the Ln(p-NO2-Bn-DOTA)- complexes lies in an equatorial position and effectively "locks" the conformation of the ring into the δδδδ configuration. The presence of the p-NO 2-benzyl group also increases the population of the square antiprismatic (SAP) coordination isomer for all Ln(p-NO 2-Bn-DOTA)- complexes relative to that seen for the respective LnDOTA- complexes. Despite this increase in SAP isomer population, the rate of water exchange in these complexes remains comparatively fast. The kinetic and thermodynamic stabilities of the Ln(p-NO 2-Bn-DOTA)- complexes are also slightly lower than the corresponding LnDOTA- complexes but appear to be sufficiently high for in vivo use.

Original languageEnglish (US)
Pages (from-to)2845-2851
Number of pages7
JournalInorganic Chemistry
Volume43
Issue number9
DOIs
StatePublished - May 3 2004
Externally publishedYes

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Lanthanoid Series Elements
Isomers
rings
isomers
Conformations
Thermodynamic stability
Kinetics
Water
thermodynamics
kinetics
configurations
water
2-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Solution Dynamics and Stability of Lanthanide(III) (S)-2-(p-Nitrobenzyl)DOTA Complexes. / Woods, Mark; Kovacs, Zoltan; Kiraly, Robert; Brücher, Ernö; Zhang, Shanrong; Sherry, A. Dean.

In: Inorganic Chemistry, Vol. 43, No. 9, 03.05.2004, p. 2845-2851.

Research output: Contribution to journalArticle

Woods, M, Kovacs, Z, Kiraly, R, Brücher, E, Zhang, S & Sherry, AD 2004, 'Solution Dynamics and Stability of Lanthanide(III) (S)-2-(p-Nitrobenzyl)DOTA Complexes', Inorganic Chemistry, vol. 43, no. 9, pp. 2845-2851. https://doi.org/10.1021/ic0353007
Woods, Mark ; Kovacs, Zoltan ; Kiraly, Robert ; Brücher, Ernö ; Zhang, Shanrong ; Sherry, A. Dean. / Solution Dynamics and Stability of Lanthanide(III) (S)-2-(p-Nitrobenzyl)DOTA Complexes. In: Inorganic Chemistry. 2004 ; Vol. 43, No. 9. pp. 2845-2851.
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AU - Zhang, Shanrong

AU - Sherry, A. Dean

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