Soluble mediators of inflammation during tumor development

Stephen C. Robinson, Lisa M. Coussens

Research output: Chapter in Book/Report/Conference proceedingChapter

96 Scopus citations

Abstract

Tissues maintain homeostasis by monitoring and responding to varied physical interactions between cells and their microenvironment. In situations where acute tissue damage occurs, such as wounding, pathogenic assault, or toxic exposure, regulatory circuits that monitor tissue homeostasis are rapidly engaged to initiate tissue repair by regulating cell polarity, proliferation and death, matrix metabolism, inflammation, and vascular and lymphatic function. The critical feature of regulating these acute responses is the innate ability to discriminate between homeostatic versus damaged tissue states and engage or disengage regulatory machinery as appropriate; thus, a major distinction between acute versus chronic disease is the altered ability to appropriately activate and/ or inactivate reparative regulatory programs. Since cancer is a chronic disease characterized by altered cell polarity, enhanced cell survival, inflammation, increased matrix metabolism, and enhanced vascular and lymphatic function, considerable attention is now focused on understanding the cellular and molecular mechanisms regulating these responsive pathways. Since chemoattractant cytokines are important mediators of leukocyte recruitment following acute tissue stress, and demonstrate altered characteristics of expression and activation in chronically inflamed tissue, they have been implicated as key regulators of inflammation and angiogenesis during cancer development. This chapter focuses on the clinical and experimental data implicating proinflammatory cytokines and chemokines as important potentiators of carcinogenesis.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages159-187
Number of pages29
DOIs
StatePublished - Jan 1 2005

Publication series

NameAdvances in Cancer Research
Volume93
ISSN (Print)0065-230X

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Robinson, S. C., & Coussens, L. M. (2005). Soluble mediators of inflammation during tumor development. In Advances in Cancer Research (pp. 159-187). (Advances in Cancer Research; Vol. 93). Academic Press Inc.. https://doi.org/10.1016/S0065-230X(05)93005-4