Solid tissues removed from Atm homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations

Mitchell Turker, Blythe M. Gage, Jennifer A. Rose, Olga N. Ponomareva, Jay A. Tischfield, Peter J. Stambrook, Carrolee Barlow, Anthony Wynshaw-Boris

Research output: Contribution to journalArticle

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Abstract

The presence of increased frequencies of blood-derived and solid tumors in ataxia-telangiectasia (A-T) patients, coupled with a role for the ATM (A-T mutation) protein in detecting specific forms of DNA damage, has led to the assumption of a mutator phenotype in A TM-deficient cells. Supporting this assumption are observations of increased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in the cells of A-T patients. We have bred mice with knockout mutations for the selectable Aprt (adenine phosphoribosyltransferase) locus and the Atm locus to examine the frequency of second-step autosomal mutations in Amt-deficient cells. Two solid tissues were examined: (a) the ear, which yields predominately mesenchymal cells; and (b) the kidney, which yields predominately epithelial cells. We report here the lack of a mutator phenotype for inactivating autosomal mutations in solid tissues of the Atm-deficient mice.

Original languageEnglish (US)
Pages (from-to)4781-4783
Number of pages3
JournalCancer Research
Volume59
Issue number19
StatePublished - Oct 1 1999

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Phenotype
Mutation
Adenine Phosphoribosyltransferase
Ataxia Telangiectasia
Knockout Mice
Chromosome Aberrations
DNA Damage
Ear
Epithelial Cells
Kidney
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Turker, M., Gage, B. M., Rose, J. A., Ponomareva, O. N., Tischfield, J. A., Stambrook, P. J., ... Wynshaw-Boris, A. (1999). Solid tissues removed from Atm homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. Cancer Research, 59(19), 4781-4783.

Solid tissues removed from Atm homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. / Turker, Mitchell; Gage, Blythe M.; Rose, Jennifer A.; Ponomareva, Olga N.; Tischfield, Jay A.; Stambrook, Peter J.; Barlow, Carrolee; Wynshaw-Boris, Anthony.

In: Cancer Research, Vol. 59, No. 19, 01.10.1999, p. 4781-4783.

Research output: Contribution to journalArticle

Turker, M, Gage, BM, Rose, JA, Ponomareva, ON, Tischfield, JA, Stambrook, PJ, Barlow, C & Wynshaw-Boris, A 1999, 'Solid tissues removed from Atm homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations', Cancer Research, vol. 59, no. 19, pp. 4781-4783.
Turker M, Gage BM, Rose JA, Ponomareva ON, Tischfield JA, Stambrook PJ et al. Solid tissues removed from Atm homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. Cancer Research. 1999 Oct 1;59(19):4781-4783.
Turker, Mitchell ; Gage, Blythe M. ; Rose, Jennifer A. ; Ponomareva, Olga N. ; Tischfield, Jay A. ; Stambrook, Peter J. ; Barlow, Carrolee ; Wynshaw-Boris, Anthony. / Solid tissues removed from Atm homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. In: Cancer Research. 1999 ; Vol. 59, No. 19. pp. 4781-4783.
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