Sodium channel-blocking agents: Their use in neuropathic pain conditions

D. L. Tanelian, R. A. Victory, Kim Burchiel, C. Chabal, M. Devor, S. M. Weinstein

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Neuropathic pain conditions are due to damage or permanent alteration of the peripheral or central nervous system. These conditions are generally chronic and less responsive to opiates than nociceptive (acute) pain conditions; as such, they are very difficult to treat clinically. Numerous classes of drugs, including opiates, antidepressants, anticonvulsants, local anesthetics, antiarrhythmics, steroids, antipsychotic agents, and topical capsaicin have been used to treat neuropathic pain. One mechanism common to several of these pharmacological agents is their ability to block sodium channels in a use-dependent fashion. In this focus article clinical evidence of the effectiveness of sodium channel-blocking drugs for relieving neuropathic pain will be presented. Experimental evidence for the site of action of these drugs will be discussed, along with future studies that are needed to develop new, more effective, agents.

Original languageEnglish (US)
Pages (from-to)75-89
Number of pages15
JournalPain Forum
Volume4
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Opiate Alkaloids
Sodium Channels
Neuralgia
Pharmaceutical Preparations
Nociceptive Pain
Capsaicin
Peripheral Nervous System
Acute Pain
Local Anesthetics
Anticonvulsants
Antidepressive Agents
Antipsychotic Agents
Central Nervous System
Steroids
Pharmacology

Keywords

  • carbamazepine
  • chronic pain
  • lidocaine
  • local anesthetics
  • mexiletine
  • neuropathic pain
  • phenytoin
  • procaine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Tanelian, D. L., Victory, R. A., Burchiel, K., Chabal, C., Devor, M., & Weinstein, S. M. (1995). Sodium channel-blocking agents: Their use in neuropathic pain conditions. Pain Forum, 4(2), 75-89.

Sodium channel-blocking agents : Their use in neuropathic pain conditions. / Tanelian, D. L.; Victory, R. A.; Burchiel, Kim; Chabal, C.; Devor, M.; Weinstein, S. M.

In: Pain Forum, Vol. 4, No. 2, 1995, p. 75-89.

Research output: Contribution to journalArticle

Tanelian, DL, Victory, RA, Burchiel, K, Chabal, C, Devor, M & Weinstein, SM 1995, 'Sodium channel-blocking agents: Their use in neuropathic pain conditions', Pain Forum, vol. 4, no. 2, pp. 75-89.
Tanelian DL, Victory RA, Burchiel K, Chabal C, Devor M, Weinstein SM. Sodium channel-blocking agents: Their use in neuropathic pain conditions. Pain Forum. 1995;4(2):75-89.
Tanelian, D. L. ; Victory, R. A. ; Burchiel, Kim ; Chabal, C. ; Devor, M. ; Weinstein, S. M. / Sodium channel-blocking agents : Their use in neuropathic pain conditions. In: Pain Forum. 1995 ; Vol. 4, No. 2. pp. 75-89.
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