Sodium and Water Regulation in a Patient With Cerebral Salt Wasting

Michael Diringer, Daniel F. Hanley, Cecil Borel, Graeme K. Hart, Jeffrey Kirsch, Paul W. Ladenson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Hyponatremia, in patients with central nervous system disease, can be attributable to impaired free water excretion (syndrome of inappropriate secretion of antidiuretic hormone) or to excessive sodium excretion (cerebral salt wasting). We present a patient with a parietal glioma and hyponatremia characterized by salt wasting and dehydration. Rehydration and sodium repletion corrected the sodium and volume deficits; withdrawal of supplemental sodium resulted in recurrence of dehydration and hyponatremia. We determined sodium and water balance and measured plasma atriopeptin, antidiuretic hormone, and aldosterone. Plasma atriopeptin ranged from 8 to 44 pg/mL (normal, 45 pg/mL); antidiuretic hormone was not elevated at 4 to 5 pg/mL, and aldosterone was slightly elevated at 1040.25 pmol/L. The concentrations of these hormones could not directly explain the natriuresis; interactions with neural or other humoral factors may be involved. In evaluating such patients, careful attention to sodium and water balance is important to guide appropriate therapy.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalArchives of Neurology
Volume46
Issue number8
DOIs
StatePublished - 1989
Externally publishedYes

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Salts
Sodium
Hyponatremia
Water
Atrial Natriuretic Factor
Aldosterone
Vasopressins
Dehydration
Inappropriate ADH Syndrome
Natriuresis
Fluid Therapy
Central Nervous System Diseases
Glioma
Hormones
Salt
Recurrence
Plasma
Therapeutics

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sodium and Water Regulation in a Patient With Cerebral Salt Wasting. / Diringer, Michael; Hanley, Daniel F.; Borel, Cecil; Hart, Graeme K.; Kirsch, Jeffrey; Ladenson, Paul W.

In: Archives of Neurology, Vol. 46, No. 8, 1989, p. 928-930.

Research output: Contribution to journalArticle

Diringer, Michael ; Hanley, Daniel F. ; Borel, Cecil ; Hart, Graeme K. ; Kirsch, Jeffrey ; Ladenson, Paul W. / Sodium and Water Regulation in a Patient With Cerebral Salt Wasting. In: Archives of Neurology. 1989 ; Vol. 46, No. 8. pp. 928-930.
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