Social setting, social rank and HPA axis response in cynomolgus monkeys

Vanessa A. Jimenez, Daicia C. Allen, Megan N. McClintick, Kathleen (Kathy) Grant

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Rationale: Hypothalamic-pituitary-adrenal (HPA) axis activity under different social settings in non-human primates is understudied. Objective: The aim of this study is to evaluate the response of pituitary-adrenal hormones (adrenocorticotropic hormone (ACTH) and cortisol) to pharmacological challenges of the HPA axis in male cynomolgus macaques under different social settings. Methods: Male cynomolgus macaques (Macaca fascicularis, n = 11) were individually (A) and socially housed (B) in alternation, over consecutive months, in an ABA design. During each experimental phase, plasma ACTH and cortisol were measured in response to low- and mild-intensity psychological stressors and following administration of saline, naloxone, ovine-corticotropin-releasing factor (oCRF), and dexamethasone. Results: These data demonstrate that cortisol measured under low stress conditions is sensitive to social rank (dominance hierarchy) and distinguishes dominant from non-dominant animals during both individual and social settings. Administration of naloxone resulted in elevated circulating ACTH and cortisol, while oCRF only increased circulating cortisol. During social housing, the cortisol response to naloxone and oCRF was increased, whereas dexamethasone suppression of ACTH and cortisol remained consistent across all social settings. Conclusions: Circulating ACTH and cortisol are differentially sensitive to changes in social settings in non-human primates. Cortisol response increased during social housing and could be stimulated by both naloxone and oCRF, whereas ACTH response was generally not influenced by social setting or oCRF but was increased by naloxone. These data show differential adrenal and pituitary response to changes in social settings and a small, but consistent, effect of social dominance.

    Original languageEnglish (US)
    Pages (from-to)1-9
    Number of pages9
    JournalPsychopharmacology
    DOIs
    StateAccepted/In press - Mar 22 2017

    Fingerprint

    Macaca fascicularis
    Hydrocortisone
    Corticotropin-Releasing Hormone
    Adrenocorticotropic Hormone
    Naloxone
    Social Dominance
    Sheep
    Macaca
    Dexamethasone
    Primates
    Pituitary Hormones
    Pharmacology
    Psychology

    Keywords

    • ACTH
    • Cortisol
    • HPA axis
    • Monkey
    • Social rank

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Social setting, social rank and HPA axis response in cynomolgus monkeys. / Jimenez, Vanessa A.; Allen, Daicia C.; McClintick, Megan N.; Grant, Kathleen (Kathy).

    In: Psychopharmacology, 22.03.2017, p. 1-9.

    Research output: Contribution to journalArticle

    Jimenez, Vanessa A. ; Allen, Daicia C. ; McClintick, Megan N. ; Grant, Kathleen (Kathy). / Social setting, social rank and HPA axis response in cynomolgus monkeys. In: Psychopharmacology. 2017 ; pp. 1-9.
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    abstract = "Rationale: Hypothalamic-pituitary-adrenal (HPA) axis activity under different social settings in non-human primates is understudied. Objective: The aim of this study is to evaluate the response of pituitary-adrenal hormones (adrenocorticotropic hormone (ACTH) and cortisol) to pharmacological challenges of the HPA axis in male cynomolgus macaques under different social settings. Methods: Male cynomolgus macaques (Macaca fascicularis, n = 11) were individually (A) and socially housed (B) in alternation, over consecutive months, in an ABA design. During each experimental phase, plasma ACTH and cortisol were measured in response to low- and mild-intensity psychological stressors and following administration of saline, naloxone, ovine-corticotropin-releasing factor (oCRF), and dexamethasone. Results: These data demonstrate that cortisol measured under low stress conditions is sensitive to social rank (dominance hierarchy) and distinguishes dominant from non-dominant animals during both individual and social settings. Administration of naloxone resulted in elevated circulating ACTH and cortisol, while oCRF only increased circulating cortisol. During social housing, the cortisol response to naloxone and oCRF was increased, whereas dexamethasone suppression of ACTH and cortisol remained consistent across all social settings. Conclusions: Circulating ACTH and cortisol are differentially sensitive to changes in social settings in non-human primates. Cortisol response increased during social housing and could be stimulated by both naloxone and oCRF, whereas ACTH response was generally not influenced by social setting or oCRF but was increased by naloxone. These data show differential adrenal and pituitary response to changes in social settings and a small, but consistent, effect of social dominance.",
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