Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys

Christa Helms, Megan N. McClintick, Kathleen (Kathy) Grant

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Rationale: Dominance hierarchies affect ethanol self-administration, with greater intake among subordinate animals compared to dominant animals. Excessive ethanol intake disrupts circadian rhythms. Diurnal rhythms of the hypothalamic-pituitary-adrenal axis have not been characterized in the context of ethanol self-administration with regard to social rank. Objective: This study aimed to determine whether diurnal pituitary-adrenal hormonal rhythms account for differences between social ranks in ethanol self-administration or are differentially affected by ethanol self-administration between social ranks. Methods: During alternating individual (n∈=∈11-12) and social (n∈=∈3 groups) housing of male cynomolgus monkeys (Macaca fascicularis), diurnal measures of cortisol and adrenocorticotropic hormone (ACTH) were obtained from plasma samples three times per week. Social rank was determined, ethanol (4 %, w/v) self-administration was induced, and then the monkeys were allowed a choice of water or ethanol for 22 h/day for 49 weeks. Results: For all social ranks, plasma ACTH was elevated during social housing, but cortisol was stable, although greater among dominant monkeys. Ethanol self-administration blunted the effect of social housing, cortisol, and the diurnal rhythm for both hormones, regardless of daily ethanol intake (1.2-4.2 g/kg/day). Peak ACTH and cortisol were more likely to be observed in the morning during ethanol access. Ethanol, not vehicle, intake was lower during social housing across social ranks. Only dominant monkeys showed significantly lower blood-ethanol concentration during social housing. Conclusions: There was a low threshold for disruption of diurnal pituitary rhythms by ethanol drinking, but sustained adrenal corticosteroid rhythms. Protection against heavy drinking among dominant monkeys may have constrained ethanol intoxication, possibly to preserve dominance rank.

    Original languageEnglish (US)
    Pages (from-to)133-143
    Number of pages11
    JournalPsychopharmacology
    Volume224
    Issue number1
    DOIs
    StatePublished - Nov 2012

    Fingerprint

    Self Administration
    Macaca fascicularis
    Ethanol
    Circadian Rhythm
    Haplorhini
    Hydrocortisone
    Adrenocorticotropic Hormone
    Drinking
    Social Dominance

    Keywords

    • ACTH
    • Cortisol
    • Ethanol
    • HPA axis
    • Monkey
    • Stress

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. / Helms, Christa; McClintick, Megan N.; Grant, Kathleen (Kathy).

    In: Psychopharmacology, Vol. 224, No. 1, 11.2012, p. 133-143.

    Research output: Contribution to journalArticle

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    abstract = "Rationale: Dominance hierarchies affect ethanol self-administration, with greater intake among subordinate animals compared to dominant animals. Excessive ethanol intake disrupts circadian rhythms. Diurnal rhythms of the hypothalamic-pituitary-adrenal axis have not been characterized in the context of ethanol self-administration with regard to social rank. Objective: This study aimed to determine whether diurnal pituitary-adrenal hormonal rhythms account for differences between social ranks in ethanol self-administration or are differentially affected by ethanol self-administration between social ranks. Methods: During alternating individual (n∈=∈11-12) and social (n∈=∈3 groups) housing of male cynomolgus monkeys (Macaca fascicularis), diurnal measures of cortisol and adrenocorticotropic hormone (ACTH) were obtained from plasma samples three times per week. Social rank was determined, ethanol (4 {\%}, w/v) self-administration was induced, and then the monkeys were allowed a choice of water or ethanol for 22 h/day for 49 weeks. Results: For all social ranks, plasma ACTH was elevated during social housing, but cortisol was stable, although greater among dominant monkeys. Ethanol self-administration blunted the effect of social housing, cortisol, and the diurnal rhythm for both hormones, regardless of daily ethanol intake (1.2-4.2 g/kg/day). Peak ACTH and cortisol were more likely to be observed in the morning during ethanol access. Ethanol, not vehicle, intake was lower during social housing across social ranks. Only dominant monkeys showed significantly lower blood-ethanol concentration during social housing. Conclusions: There was a low threshold for disruption of diurnal pituitary rhythms by ethanol drinking, but sustained adrenal corticosteroid rhythms. Protection against heavy drinking among dominant monkeys may have constrained ethanol intoxication, possibly to preserve dominance rank.",
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