Social dominance in dlonheys: Dopamine D2 receptors and cocaine self-administration

Drake Morgan, Kathleen (Kathy) Grant, H. Donald Gage, Robert H. Mach, Jay R. Kaplan, Osric Prioleau, Susan H. Nader, Nancy Buchheimer, Richard L. Ehrenkaufer, Michael A. Nader

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Disruption of the dopaminergic system has been implicated in the etiology of many pathological conditions, including drug addiction. Here we used positron emission tomography (PET) imaging to study brain dopaminergic function in individually housed and in socially housed cynomolgus macaques (n = 20). Whereas the monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced no change in subordinate monkeys. These neurobiological changes had an important behavioral influence as demonstrated by the finding that cocaine functioned as a reinforcer in subordinate but not dominant monkeys. These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction.

Original languageEnglish (US)
Title of host publicationSocial Neuroscience: Key Readings
PublisherTaylor and Francis
Pages243-252
Number of pages10
ISBN (Print)9780203496190
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Social Dominance
Self Administration
Dopamine D2 Receptors
Cocaine
Haplorhini
Cocaine-Related Disorders
Macaca
Positron-Emission Tomography
Substance-Related Disorders
Brain

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Morgan, D., Grant, K. K., Gage, H. D., Mach, R. H., Kaplan, J. R., Prioleau, O., ... Nader, M. A. (2013). Social dominance in dlonheys: Dopamine D2 receptors and cocaine self-administration. In Social Neuroscience: Key Readings (pp. 243-252). Taylor and Francis. https://doi.org/10.4324/9780203496190

Social dominance in dlonheys : Dopamine D2 receptors and cocaine self-administration. / Morgan, Drake; Grant, Kathleen (Kathy); Gage, H. Donald; Mach, Robert H.; Kaplan, Jay R.; Prioleau, Osric; Nader, Susan H.; Buchheimer, Nancy; Ehrenkaufer, Richard L.; Nader, Michael A.

Social Neuroscience: Key Readings. Taylor and Francis, 2013. p. 243-252.

Research output: Chapter in Book/Report/Conference proceedingChapter

Morgan, D, Grant, KK, Gage, HD, Mach, RH, Kaplan, JR, Prioleau, O, Nader, SH, Buchheimer, N, Ehrenkaufer, RL & Nader, MA 2013, Social dominance in dlonheys: Dopamine D2 receptors and cocaine self-administration. in Social Neuroscience: Key Readings. Taylor and Francis, pp. 243-252. https://doi.org/10.4324/9780203496190
Morgan D, Grant KK, Gage HD, Mach RH, Kaplan JR, Prioleau O et al. Social dominance in dlonheys: Dopamine D2 receptors and cocaine self-administration. In Social Neuroscience: Key Readings. Taylor and Francis. 2013. p. 243-252 https://doi.org/10.4324/9780203496190
Morgan, Drake ; Grant, Kathleen (Kathy) ; Gage, H. Donald ; Mach, Robert H. ; Kaplan, Jay R. ; Prioleau, Osric ; Nader, Susan H. ; Buchheimer, Nancy ; Ehrenkaufer, Richard L. ; Nader, Michael A. / Social dominance in dlonheys : Dopamine D2 receptors and cocaine self-administration. Social Neuroscience: Key Readings. Taylor and Francis, 2013. pp. 243-252
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