SNAP-25 is present on the Golgi apparatus of retinal neurons

Catherine Morgans, Johann H. Brandstätter

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

SNAP-25 is a neuronal SNARE protein required for synaptic vesicle exocytosis and neurite outgrowth. Here we show that in addition to synaptic staining, SNAP-25 immunoreactivity is also localized to an intracellular, perinuclear compartment of retinal neurons. Double-labeling with an antibody against the 58 kD resident protein of the trans-golgi network indicates that the intracellular SNAP-25 is localized to the Golgi complex. Immuno-electron microscopic localization of SNAP-25 confirmed its presence on the Golgi apparatus of photoreceptors, bipolar cells, amacrine cells and ganglion cells in the retina. These data implicate SNAP-25 in the trafficking of Golgi- derived vesicles in neurons in addition to the synaptic vesicle cycle.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalNeuroReport
Volume11
Issue number1
DOIs
StatePublished - Jan 17 2000
Externally publishedYes

Keywords

  • Golgi
  • Neurons
  • Rat
  • Retina
  • SNAP-25

ASJC Scopus subject areas

  • Neuroscience(all)

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