SNAP-25 is present on the Golgi apparatus of retinal neurons

Catherine Morgans, Johann H. Brandstätter

    Research output: Contribution to journalArticle

    15 Scopus citations

    Abstract

    SNAP-25 is a neuronal SNARE protein required for synaptic vesicle exocytosis and neurite outgrowth. Here we show that in addition to synaptic staining, SNAP-25 immunoreactivity is also localized to an intracellular, perinuclear compartment of retinal neurons. Double-labeling with an antibody against the 58 kD resident protein of the trans-golgi network indicates that the intracellular SNAP-25 is localized to the Golgi complex. Immuno-electron microscopic localization of SNAP-25 confirmed its presence on the Golgi apparatus of photoreceptors, bipolar cells, amacrine cells and ganglion cells in the retina. These data implicate SNAP-25 in the trafficking of Golgi- derived vesicles in neurons in addition to the synaptic vesicle cycle.

    Original languageEnglish (US)
    Pages (from-to)85-88
    Number of pages4
    JournalNeuroReport
    Volume11
    Issue number1
    DOIs
    StatePublished - Jan 17 2000

    Keywords

    • Golgi
    • Neurons
    • Rat
    • Retina
    • SNAP-25

    ASJC Scopus subject areas

    • Neuroscience(all)

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