Small pulmonary nodules on CT accompanying surgically resectable lung cancer

Likelihood of malignancy

Young Han Kim, Kyung Soo Lee, Steven Primack, Hojoong Kim, O. Jung Kwon, Tae Sung Kim, Eun A. Kim, Jhingook Kim, Young Mog Shim

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The aim of this study was to determine the likelihood of malignancy in small nodules in the nonprimary lobe in patients with resectable bronchogenic carcinoma. In 141 patients who underwent curative resection of bronchogenic carcinoma and had adequate follow-up CT examinations, the presence of small nodules in the nonprimary lobe preoperatively and change of preexisting nodules, if any, was assessed. The criteria used to determine benignity of a nodule was stability or decrease in size for 24 months on CT. Histopathology of the nodules was reviewed for an additional 10 patients who underwent surgical biopsy for an accompanying nodule before curative surgery. Sixty-two (44%) of 141 patients had a total of 138 small (≤ 10 mm) nodules in the nonprimary lobes (<5 mm in 113, 5-10 mm in 25). Of these 138 nodules, 132 were benign with only six nodules malignant (with histopathologic confirmation for the enlarging nodules). The 132 benign nodules showed no change (n = 120), decrease in size (n = 11), or increase in size (n = 1) on follow-up studies, with the single enlarging nodule proved benign on biopsy. In 10 patients who had a preoperative biopsy of a single preexisting nodule in the nonprimary lobe (<5 mm = 1; 5-10 mm = 5; > 10 mm = 4) two proved to be malignant (both > 10 mm) and eight were benign. Most small (<10 mm) nodules associated with resectable bronchogenic carcinoma are benign, consistent with published results of other studies. However, a small number of nodules are malignant and CT does not reliably distinguish between benign and malignant nodules.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalJournal of Thoracic Imaging
Volume17
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

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Bronchogenic Carcinoma
Lung Neoplasms
Lung
Neoplasms
Biopsy

Keywords

  • Lung neoplasms-CT
  • Lung neoplasms-Staging
  • Lung neoplasms-Surgery
  • Lung neoplasmsMetastasis
  • Lung-CT
  • Lung-Nodules

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine
  • Radiological and Ultrasound Technology

Cite this

Small pulmonary nodules on CT accompanying surgically resectable lung cancer : Likelihood of malignancy. / Kim, Young Han; Lee, Kyung Soo; Primack, Steven; Kim, Hojoong; Kwon, O. Jung; Kim, Tae Sung; Kim, Eun A.; Kim, Jhingook; Shim, Young Mog.

In: Journal of Thoracic Imaging, Vol. 17, No. 1, 2002, p. 40-46.

Research output: Contribution to journalArticle

Kim, Young Han ; Lee, Kyung Soo ; Primack, Steven ; Kim, Hojoong ; Kwon, O. Jung ; Kim, Tae Sung ; Kim, Eun A. ; Kim, Jhingook ; Shim, Young Mog. / Small pulmonary nodules on CT accompanying surgically resectable lung cancer : Likelihood of malignancy. In: Journal of Thoracic Imaging. 2002 ; Vol. 17, No. 1. pp. 40-46.
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abstract = "The aim of this study was to determine the likelihood of malignancy in small nodules in the nonprimary lobe in patients with resectable bronchogenic carcinoma. In 141 patients who underwent curative resection of bronchogenic carcinoma and had adequate follow-up CT examinations, the presence of small nodules in the nonprimary lobe preoperatively and change of preexisting nodules, if any, was assessed. The criteria used to determine benignity of a nodule was stability or decrease in size for 24 months on CT. Histopathology of the nodules was reviewed for an additional 10 patients who underwent surgical biopsy for an accompanying nodule before curative surgery. Sixty-two (44{\%}) of 141 patients had a total of 138 small (≤ 10 mm) nodules in the nonprimary lobes (<5 mm in 113, 5-10 mm in 25). Of these 138 nodules, 132 were benign with only six nodules malignant (with histopathologic confirmation for the enlarging nodules). The 132 benign nodules showed no change (n = 120), decrease in size (n = 11), or increase in size (n = 1) on follow-up studies, with the single enlarging nodule proved benign on biopsy. In 10 patients who had a preoperative biopsy of a single preexisting nodule in the nonprimary lobe (<5 mm = 1; 5-10 mm = 5; > 10 mm = 4) two proved to be malignant (both > 10 mm) and eight were benign. Most small (<10 mm) nodules associated with resectable bronchogenic carcinoma are benign, consistent with published results of other studies. However, a small number of nodules are malignant and CT does not reliably distinguish between benign and malignant nodules.",
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